Behavioral and endocrine consequences of placentophagia in male California mice (Peromyscus californicus).
Behavioral and endocrine consequences of placentophagia in male California mice (Peromyscus californicus).
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雄性加州小鼠（Peromyscus californicus）胎盘吞食的行为和内分泌后果。
DOI：
10.1016/j.physbeh.2018.02.022
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发表时间：
2018
影响因子：
2.9
通讯作者：
Saltzman,Wendy
中科院分区：
文献类型：
--
作者：
Perea-Rodriguez,JuanP;Zhao,Meng;Harris,BreannaN;Raqueno,Joel;Saltzman,Wendy
哺乳动物母亲摄入胎盘会导致疼痛敏感性、激素水平和对新生儿的行为反应发生变化。在一些双亲哺乳动物中，除了雌性动物之外，雄性动物在其后代出生时也会摄取胎盘。在一夫一妻制的双亲加州小鼠（Peromyscus californicus）中，雄性在与其怀孕配偶同居时首先被胎盘吸引，并且给予胎盘的处女雄性比给予油媒介物的雄性更少的新恐惧。在这项研究中，我们调查了胎盘吞噬对疼痛敏感性，焦虑样行为，对幼崽的行为反应，以及繁殖和非繁殖雄性加州小鼠的循环皮质酮水平的影响。我们口服给予同种胎盘或油媒介物的雄性小鼠从三个生殖条件（第一次父亲，第一次准父亲，和处女男性），并测试他们的疼痛敏感性1小时后，以及他们的探索行为和父亲的反应在一个开放的领域4小时后处理。我们在旷场试验后立即测量血浆皮质酮。我们发现，胎盘处理的男性，独立的生殖条件，旅行显着更长的距离在开放的领域比男性油处理，表明较低的焦虑。此外，父亲接近和照顾幼崽的时间较短（即，蜷缩和舔小狗），并花更多的时间从事这些行为，比年龄匹配的准爸爸和处女男性，独立的治疗。我们发现，治疗或生殖条件对血浆皮质酮水平或疼痛敏感性没有影响。这些发现表明胎盘摄入减少了雄性加州小鼠的焦虑相关行为，但可能不影响疼痛敏感性、父性反应或血浆皮质酮浓度。
Ingestion of placenta by mammalian mothers can lead to changes in pain sensitivity, hormone levels, and behavioral responses to newborns. In some biparental mammals, males, in addition to females, ingest placenta when their offspring are born. In the monogamous, biparental California mouse (Peromyscus californicus), males first become attracted to placenta when cohabitating with their pregnant mate, and virgin males administered placenta are less neophobic than males given oil vehicle. In this study, we investigated the effects of placentophagia on pain sensitivity, anxiety-like behavior, behavioral responses to pups, and circulating corticosterone levels of both breeding and nonbreeding male California mice. We orally administered either a conspecific placenta or oil vehicle to male mice from three reproductive conditions (first-time fathers, first-time expectant fathers, and virgin males) and tested their pain sensitivity 1 h later, as well as their exploratory behavior and paternal responsiveness in an open field 4 h post-treatment. We measured plasma corticosterone immediately after the open-field test. We found that placenta-treated males, independent of reproductive condition, traveled significantly longer distances in the open field than males treated with oil, indicative of lower anxiety. Additionally, fathers had shorter latencies to approach and to care for pups (i.e., huddling and licking pups), and spent more time engaging in these behaviors, than did age-matched expectant fathers and virgin males, independent of treatment. We found no effect on plasma corticosterone levels or pain sensitivity as a result of either treatment or reproductive condition. These findings indicate that placenta ingestion decreases anxiety-related behaviors in male California mice, but might not influence pain sensitivity, paternal responsiveness, or plasma corticosterone concentrations.