Genetics of cell-surface antigens: Regional mapping of three components of the human cell-surface antigen complex, Al, on chromosome 11
Genetics of cell-surface antigens: Regional mapping of three components of the human cell-surface antigen complex, Al, on chromosome 11
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细胞表面抗原遗传学：人类细胞表面抗原复合物 Al 的三个成分在 11 号染色体上的区域图谱
DOI：
10.1007/bf01542970
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
T. Puck
中科院分区：
文献类型：
--
作者：
F. Kao;Carol Jones;T. Puck
对AL杂合克隆的人11号染色体上的一系列缺失突变进行了细胞遗传学分析，这些突变中的特异性标记已因诱变剂处理而丢失。这种分析已经将AL细胞表面抗原复合物的三种先前鉴定的组分定位于染色体11的指定区域：a1和a3：11 p13 → 11 pter; a2：11 q13 → 11 qter。使用这些方法，已经证实了其他人报道的人乳酸脱氢酶A在短臂上的定位。初步将该基因定位于11 p13 → 11 pter。
Cytogenetic analysis has been performed on a series of deletion mutations on human chromosome 11 of AL hybrid clones in which specific markers have been lost as a result of treatment with mutagenic agents. Such analysis has localized the three previously identified components of the AL cell-surface antigen complex to the indicated regions of chromosome 11: a1 and a3:11p13 → 11pter; a2: 11q13 → 11qter. Using these methodologies human lactic dehydrogenase A localization on the short arm as reported by others has been confirmed. Evidence is presented provisionally assigning this gene to 11p13 → 11pter.