Microbial interactions with neutrophils.
Microbial interactions with neutrophils.
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微生物与中性粒细胞的相互作用。
DOI：
10.1093/clinids/5.supplement_4.s806
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Spitznagel,JK
中科院分区：
文献类型：
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作者：
Spitznagel,JK
细菌发病机制在很大程度上取决于微生物细胞避免激活或抵抗中性粒细胞多形核粒细胞抗菌介质的能力，中性粒细胞是抵抗感染的吞噬防御的第一道防线。这些能力只能从中性粒细胞的细胞生物学角度来理解。相关的微生物机制主要在于其细胞表面和分泌物的生化结构。对这些因素进行了回顾，并强调了生化遗传分析在寻找新老问题新解决方案中的重要性。
Bacterial pathogenesis is heavily dependent on the capacities of microbial cells to avoid activating or to resist antimicrobial mediators of neutrophil polymorphonuclear granulocytes, the first line of phagocytic defense against infection. These capacities can but be understood in terms of the cell biology of neutrophils. The relevant microbial mechanism largely reside in the biochemical structures of their cell surfaces and their secretions. These factors are reviewed, and the importance of biochemical genetic analysis in seeking new solutions to old and new problems is stressed.