Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers
Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers
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DOI：
10.1016/j.yrtph.2010.04.005
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发表时间：
2010-07-01
影响因子：
3.4
通讯作者：
Unverdorben, Martin
中科院分区：
文献类型：
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作者：
Roethig, Hans J.;Koval, Tamara;Unverdorben, Martin
先前的研究表明，与不吸烟的人相比，吸烟者的白细胞计数(WBC)高出5%-30%，红细胞计数也更高。方法：本研究收集了三项类似研究的血液学数据，并分析了使用电热香烟吸烟系统(EHCSS)作为潜在的减少暴露产品(PREP)或不吸烟(与传统香烟相比)三天后对成年吸烟者WBC、其亚群、血小板、红细胞计数(RBC)和红细胞压积(HPC)的影响。结果：在长期吸烟者中，通过使用EHCSS或戒烟，较低的香烟烟雾暴露可导致WBC、中性粒细胞、淋巴细胞、血小板、RBC和红细胞压积在3天内显著下降9%。在3d内，从CC吸烟转为EHCSS吸烟或不吸烟可降低WBC，反之亦然。结论：这一临床模型可以作为一种筛选工具，以寻找新的技术，以深入了解香烟烟雾变化引起的炎症变化。(C)2010 Elsevier Inc.保留所有权利。
Previous studies indicate that cigarette smokers have a 5-30% higher white blood cell counts (WBC) compared to non-smokers and higher red blood cell counts. Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platelets, red blood cell count (RBC) and hematocrit in adult cigarette smokers three days after using an electrically heated cigarette smoking system (EHCSS) as a potential reduced exposure product (PREP) or no-smoking compared to smoking a conventional cigarette. Results: Lower exposure to cigarette smoke in adult, long term smokers, by using an EHCSS or stopping smoking, leads to statistically significant decreases of up to 9% in WBC, neutrophils, lymphocytes, platelets, RBC and hematocrit within three days. Switching from CC-smoking to EHCSS-smoking or no-smoking resulted in lower WBC and vice versa within 3 days. Conclusion: This clinical model may be used as a screening tool to find new technologies that could provide insights on changes in inflammation resulting from the change in cigarette smoke. (C) 2010 Elsevier Inc. All rights reserved.