Just So Stories about the Evolution of Apoptosis.
Just So Stories about the Evolution of Apoptosis.
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DOI：
10.1016/j.cub.2016.05.023
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发表时间：
2016-07-11
期刊：
影响因子：
--
通讯作者：
Fitzgerald P
中科院分区：
文献类型：
--
作者：
Green DR;Fitzgerald P
细胞凋亡是一种由发育线索以及许多不同的细胞应激参与的主动细胞死亡形式，其中垂死细胞基本上将其自身“包装”以去除。在分子水平上定义的凋亡性细胞死亡过程是后生动物（动物）所特有的。然而，主动细胞死亡存在于非动物生物体中，并且在某些情况下，参与这种死亡的分子显示出与参与细胞凋亡的分子的一些序列相似性，从而导致关于细胞凋亡进化的广泛推测。在这里，我们从线粒体凋亡细胞死亡途径分子的功能特性的角度来研究这种推测。我们提出了一种凋亡途径，线粒体途径的演变方案，并考虑如何测试它们。最后，我们总结了线粒体凋亡途径在真核生物进化过程中是如何进化的。
Apoptosis is a form of active cell death engaged by developmental cues as well as many different cellular stresses in which the dying cell essentially ‘packages’ itself for removal. The process of apoptotic cell death, as defined at the molecular level, is unique to the Metazoa (animals). Yet active cell death exists in non-animal organisms, and in some cases molecules involved in such death show some sequence similarities to those involved in apoptosis, leading to extensive speculation regarding the evolution of apoptosis. Here, we examine such speculation from the perspective of the functional properties of molecules of the mitochondrial apoptotic cell death pathway. We suggest scenarios for the evolution of one pathway of apoptosis, the mitochondrial pathway, and consider how they might be tested. We conclude with a ‘Just So Story’ of how the mitochondrial pathway of apoptosis might have evolved during eukaryotic evolution.