Gap junction coding genes and schizophrenia: a genetic association study
Gap junction coding genes and schizophrenia: a genetic association study
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DOI：
10.1007/s10038-007-0142-5
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Ozaki, Norio
中科院分区：
文献类型：
--
作者：
Aleksic, Branko;Ishihara, Ryoko;Ozaki, Norio
本研究的目的是评估编码间隙连接形成蛋白的基因与精神分裂症的关系。从两个间隙连接基因家族中选择具有代表性的候选基因（Panx2和Cx36）进行分析。根据目前的发现，这些基因代表了精神分裂症的功能和位置候选基因。样本由381名精神分裂症患者组成，本研究测试了相同数量的匹配对照，以评估上述基因对精神分裂症发病机制的可能影响。选择Panx2的4个snp和Cx36的2个snp进行分析。等位基因、基因型和单倍型相关没有产生统计学上显著的结果。这些数据并不表明Panx2或Cx36会增加日本人群患精神分裂症的风险。
The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (Panx2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of Panx2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population.