Stability of Atheromatous Plaque Affected by Lesional Composition
Stability of Atheromatous Plaque Affected by Lesional Composition
复制标题
病变成分影响的粥样斑块的稳定性
DOI：
10.1111/j.1749-6632.2001.tb03977.x
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发表时间：
2001
影响因子：
5.2
通讯作者：
M. Enomoto
中科院分区：
文献类型：
--
作者：
M. Shiomi;Takashi Ito;Y. Hirouchi;M. Enomoto
翻译后摘要：我们研究了病变的组成是如何与冠状动脉斑块的稳定性。WHHL兔（12月龄）口服普伐他汀和氟伐他汀52周。两种他汀类药物均使血浆胆固醇水平降低约25%，但对冠状动脉斑块程度的抑制作用轻微。普伐他汀降低纤维肌帽区巨噬细胞（Mφ）含量，氟伐他汀降低平滑肌细胞（SMC）含量。斑块易损性指数在Mφ-贫斑块中较低，但在SMC-贫斑块中较高。我们的研究结果表明，在纤维肌帽中Mφs的减少与斑块稳定有关，而在纤维肌帽中SMC的减少与斑块不稳定有关。
Abstract: We examined how lesional composition is related to the stability of coronary plaques. WHHL rabbits (12 months old) were given pravastatin and fluvastatin orally for 52 weeks. Both statins decreased plasma cholesterol levels by about 25%, but the suppressive effects on the degree of coronary plaques were mild. Macrophage (Mφ) contents in fibromuscular cap regions were decreased by pravastatin, and smooth muscle cell (SMC) contents in those were decreased by fluvastatin. The plaque vulnerability index was low in Mφ‐poor plaques, but high in SMC‐poor plaques. Our results suggest that reduction in Mφs in the fibromuscular cap is related to plaque stabilization and that reduction in SMCs in the fibromuscular cap is related to plaque destabilization.