A Pilot Randomized Trial of Ferric Citrate Coordination Complex for the Treatment of Advanced CKD
A Pilot Randomized Trial of Ferric Citrate Coordination Complex for the Treatment of Advanced CKD
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DOI：
10.1681/asn.2018101016
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发表时间：
2019-08-01
影响因子：
13.6
通讯作者：
Chertow, Glenn M.
中科院分区：
文献类型：
--
作者：
Block, Geoffrey A.;Block, Martha S.;Chertow, Glenn M.
背景研究人员尚未确定晚期CKD患者的最佳护理。有证据表明，贫血和CKD相关的矿物质代谢异常(包括磷酸盐和成纤维细胞生长因子23[FGF23]的异常)导致了该人群的不良结局。方法为了研究固定剂量的柠檬酸铁络合物是否有利于晚期CKD患者的多项生化指标，我们随机将203名患者分配到EGFR组
Background Researchers have yet to determine the optimal care of patients with advanced CKD. Evidence suggests that anemia and CKD-related disordered mineral metabolism (including abnormalities in phosphate and fibroblast growth factor 23 [FGF23]) contribute to adverse outcomes in this population.Methods To investigate whether fixed-dose ferric citrate coordination complex favorably affects multiple biochemical parameters in patients with advanced CKD, we randomly assigned 203 patients with eGFR