Squamous cell carcinoma of the eyelids
Squamous cell carcinoma of the eyelids
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DOI：
10.1136/bjo.86.10.1161
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发表时间：
2002-10-01
影响因子：
4.1
通讯作者：
Williamson, RM
中科院分区：
文献类型：
--
作者：
Donaldson, MJ;Sullivan, TJ;Williamson, RM
目的：目的：探讨眼睑鳞状细胞癌（SCC）的临床特点、治疗方法及手术治疗效果。方法：回顾性分析1992 ~ 2001年收治的50例眼睑SCC的临床资料。患者年龄范围为26 - 93岁，平均年龄为65岁。男33例，女17例。病变位于下眼睑31例，上眼睑5例，外眦6例，内眦9例。4例患者发现神经周围侵犯，3例患者发现眼眶侵犯。1例患者复发。治疗方法是完全切除，组织学证实边缘清晰。3例患者需要进行内脏清除术。无患者发生淋巴结或远处转移。一名拒绝治疗的病人因肿瘤死亡。平均随访时间为31.1个月。结论：眼睑鳞状细胞癌是一种相对罕见，但可能致命的疾病。然而，如果早期发现并得到充分治疗，预后通常很好。建议通过完全切除并经组织学证实肿瘤清除进行治疗。神经周围扩散是一个不良的预后迹象，可能需要术后放疗。眼眶侵犯是一种罕见的并发症，但如果早期发现，可以通过清除术有效治疗。由于表现各异，需要进行组织学检查。为了准确诊断，眼睑上发生的任何可疑病变都应切除或活检。所有眼睑鳞状细胞癌患者都应被告知复发或新发肿瘤的风险，并鼓励参加终身随访。预防仍然是最重要的，以尽量减少这些病变的发病率和死亡率。
Aim: To review the clinical features, management, and outcomes of surgical treatment of eyelid squamous cell carcinoma (SCC).Methods: A retrospective review of all eyelid SCCs treated between 1992 and 2001.Results: 51 cases were identified in 50 patients. Patient ages ranged from 26 to 93 years, with a mean age of 65 years. 33 patients were male and 17 were female. The lesion was found on the lower lid in 31 cases, upper lid in Five cases, lateral canthus in six cases, and medial canthus in nine cases. Perineural invasion was found in four patients, and orbital invasion in three patients. Recurrence occurred in one patient. Treatment was by complete excision with histological confirmation of clear margins. Exenteration was required in three patients. No patients developed lymph node or distant metastases. One patient, who declined treatment, died as a result of the tumour. Mean follow up was 31.1 months.Conclusions: Eyelid SCC is a relatively uncommon, but potentially fatal disease. However, if detected early and treated adequately, the prognosis is generally excellent. Treatment by complete excision with histological confirmation of tumour clearance is recommended. Perineural spread is an adverse prognostic sign, which may require postoperative radiotherapy, Orbital invasion is a rare complication but, if recognised early, can be treated effectively with exenteration. Because presentation varies and histological examination is required For accurate diagnosis, any suspicious lesion occurring on the eyelids should be excised or biopsied, All patients with eyelid SCC should be advised of the risk of recurrent or new tumours and encouraged to attend lifelong follow up. Prevention remains of prime importance in minimising the morbidity and mortality of these lesions.