Clinical efficacy and tolerability of gosha-jinki-gan, Japanese traditional herbal medicine, in females with overactive bladder.
Clinical efficacy and tolerability of gosha-jinki-gan, Japanese traditional herbal medicine, in females with overactive bladder.
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日本传统草药御车神器丸对女性膀胱过度活动症的临床疗效和耐受性。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
K. Mutaguchi
中科院分区：
文献类型：
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作者：
M. Kajiwara;K. Mutaguchi
采用经语言验证的问卷，客观分析了7.5 g/天Gosha-jinki-gan单药治疗膀胱过度活动症日本女性的疗效和耐受性。共有44名被诊断患有膀胱过度活动症的日本女性入组。治疗前后分别记录2 d的日间和睡眠时的排尿次数，并进行国际前列腺症状评分指数评分和生活质量指数评分。通过比较两组患者的生活质量指数评分进行疗效评估。国际前列腺症状评分总分、生活质量指数评分、日间和睡眠时的排尿次数均显著降低。生活质量问卷客观评价结果为优7%，改善46%，不变41%，恶化7%。不良反应发生率为9%。Gosha-jinki-gan可能是女性膀胱过度活动症的一种安全有效的潜在治疗选择。
The efficacy and tolerability of a single-agent treatment with 7.5 g/day Gosha-jinki-gan in Japanese females with overactive bladder were analyzed objectively with linguistically validated questionnaires. A total of 44 Japanese females diagnosed as having overactive bladder were enrolled. Before and after the treatment, urinary frequency during the daytime and sleep was counted for two days, and the International Prostate Symptom Score index scores and quality of life index scores were examined. The efficacy assessment was done by comparing the quality of life index scores. The total scores of International Prostate Symptom Score, quality of life index scores and urinary frequency during the daytime and sleep were significantly decreased, respectively. Objective evaluation with the quality of life questionnaire yielded a result of excellent in 7%, improved in 46%, unchanged in 41% and worsened in 7%. Adverse reactions were observed in 9%. Gosha-jinki-gan could be a safe and effective potential therapeutic alternative in females with overactive bladder.