Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive
Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive
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DOI：
10.1093/bja/aeh124
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发表时间：
2004-05-01
影响因子：
9.8
通讯作者：
Brown, RH
中科院分区：
文献类型：
--
作者：
Groeben, H;Meier, S;Brown, RH
背景资料。吸入麻醉剂的亚麻醉剂浓度显著影响呼吸对低氧和高碳酸血症的反应。具有遗传性钝性呼吸驱动的个体比正常个体更容易受到影响。为了验证钝性高碳酸血症呼吸驱动受试者受不同麻醉剂影响的假说，我们研究了三种挥发性麻醉剂对以钝性高碳酸血症呼吸反应为特征的C3H/HeJ(C3)小鼠呼吸控制的影响。用全身体积描记法测定了11只雄性C3小鼠在静息状态、异氟醚、七氟醚或地氟醚麻醉及苏醒时的呼吸频率和压力幅值。为了测试呼吸动力，小鼠暴露在8%的二氧化碳中。数据分析采用双因素方差分析、后处理检验和Bonferroni校正。七氟醚麻醉至1.0MAC时RR未受影响。同样，1.5MAC的七氟醚对RR的影响小于异氟醚(P=0.0014)或地氟醚(P=0.0048)。三种麻醉剂即使在最低浓度时也能阻断二氧化碳刺激所增加的RR，并在恢复过程中保持抑制(P
Background. Subanaesthetic concentrations of volatile anaesthetics significantly affect the respiratory response to hypoxia and hypercapnoeia. Individuals with an inherited blunted respiratory drive are more affected than normal individuals. To test the hypothesis that subjects with blunted hypercapnoeic respiratory drive are diversely affected by different anaesthetics, we studied the effects of three volatile anaesthetics on the control of breathing in C3H/HeJ (C3) mice, characterized by a blunted hypercapnoeic respiratory response.Methods. Using whole body plethysmography, we assessed respiratory rate (RR) and pressure amplitude in 11 male C3 mice at rest, during anaesthesia with isoflurane, sevoflurane or desflurane, and during recovery. To test respiratory drive, mice were exposed to 8% carbon dioxide. Data were analysed by two-way-analysis of variance with post hoc tests and Bonferroni correction.Results. RR was unaffected during sevoflurane anaesthesia up to 1.0 MAC. Likewise, sevoflurane at 1.5 MAC affected RR less than either isoflurane (P=0.0014) or desflurane (P=0.0048). The increased RR to a carbon dioxide challenge was blocked by all three anaesthetics even at the lowest concentration, and remained depressed during recovery (P