It's all in the timing: Many clocks, many outputs
It's all in the timing: Many clocks, many outputs
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DOI：
10.1177/0748730404269008
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Hogenesch, JB
中科院分区：
文献类型：
--
作者：
Panda, S;Hogenesch, JB
人们认为，生理和行为的昼夜节律赋予了使用时钟的有机体生存的优势。在哺乳动物中，驻留在SCN中的主时钟与其他中央和外围振荡器同步，以唤起这种调节。这个主振荡器由互锁的转录-翻译反馈环组成，它调节振荡器维持所需的核心时钟基因，以及在昼夜节律控制下直接或间接调节生理的特定输出基因。现在很清楚，时钟的神经解剖和分子输出都是正常的昼夜节律时钟功能所必需的。最近的技术提高了我们对这些过程的理解，阐明了SCN的解剖输出，以及调节观察到的生理变化的中枢和外周振荡器的分子输出。
It is thought that circadian regulation of physiology and behavior imparts survival advantages to organisms that use clocks. In mammals, a master clock resident in the SCN synchronizes other central and peripheral oscillators to evoke this regulation. This master oscillator consists of interlocking transcriptional-translational feedback loops, and it regulates both core clock genes necessary for oscillator maintenance as well as specific output genes that directly or indirectly mediate physiology under circadian control. It is now clear that both neuroanatomic and molecular outputs of the clock are necessary for proper circadian clock function. Recent technology has improved our understanding of these processes, elucidating the anatomic outputs of the SCN, as well as the molecular outputs of both central and peripheral oscillators that mediate observed physiological changes.