Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach.
Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach.
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通过机械干涂方法降低粉末的内在内聚力，改善药物粉末的气雾化。
DOI：
10.1016/j.ijpharm.2010.04.032
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发表时间：
2010
影响因子：
5.8
通讯作者：
D. Morton
中科院分区：
文献类型：
--
作者：
Q. Zhou;Li Qu;I. Larson;P. Stewart;D. Morton
本研究的目的是研究包衣对三种模型微粉雾化的影响。选择了三种模型粉末材料（硫酸沙丁胺醇、昔萘酸沙美特罗、曲安奈德），不仅因为它们具有不同的化学性质，而且因为它们具有不同的物理性质，如形状和粒度分布。使用两种不同的干法机械融合方法，用5%（w/w）硬脂酸镁涂覆每种粉末。机械融合后，所有三种模型药物粉末的倾倒密度和振实密度均显著增加。机械融合后，所有模型粉末的吸入器装置的雾化行为均有显著改善。雾化的这种改进归因于通过表面改性降低粉末固有内聚力而引起的团聚体强度的降低。研究还表明，涂层的效果取决于颗粒的初始性质。
The aim of this study was to investigate the effect of coating on the aerosolization of three model micronized powders. Three model powder materials (salbutamol sulphate, salmeterol xinafoate, triamcinolone acetonide) were chosen not only for their different chemical properties but also for their different physical properties such as shape and size distribution. Each powder was coated with 5% (w/w) magnesium stearate using two different dry mechanofusion approaches. After mechanofusion, both poured and tapped densities for all three model drug powders significantly increased. There were significant improvements in aerosolization behavior from an inhaler device for all model powders after mechanofusion. Such improvements in aerosolization were attributed to the reduction in agglomerate strength caused by decreasing powder intrinsic cohesion via surface modification. The work also indicated that the effect of the coating was dependant on the initial particle properties.
影响因子：
56.9
作者：
Edwards, DA;Hanes, J;Langer, R
通讯作者：
Langer, R