Cutting edge:: CD28 controls peripheral homeostasis of CD4+CD25+
Cutting edge:: CD28 controls peripheral homeostasis of CD4+CD25+
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DOI：
10.4049/jimmunol.171.7.3348
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发表时间：
2003-10-01
影响因子：
4.4
通讯作者：
Bluestone, JA
中科院分区：
文献类型：
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作者：
Tang, QZ;Henriksen, KJ;Bluestone, JA
在非肥胖糖尿病小鼠品系中，CD 28/B7阻断导致自身免疫性疾病加重，这是由于CD 4（+）CD 25（+）调节性T细胞数量显著减少（TcB）。在此，我们证明，CD 28控制胸腺发育和外周稳态的胸腺。CD 28通过支持它们的存活和促进它们的自我更新来维持外周T细胞的稳定库。CD 28参与通过调节常规T细胞的IL-2产生和TcB上的CD 25表达来促进存活。
CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+) CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.