Adaptations to endurance training depend on exercise-induced oxidative stress: exploiting redox interindividual variability
Adaptations to endurance training depend on exercise-induced oxidative stress: exploiting redox interindividual variability
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DOI：
10.1111/apha.12898
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发表时间：
2018-02-01
影响因子：
6.3
通讯作者：
Nikolaidis, M. G.
中科院分区：
文献类型：
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作者：
Margaritelis, N. V.;Theodorou, A. A.;Nikolaidis, M. G.
AimThe本研究的目的是揭示活性氧和氮的物种（RONS）在运动适应生理条件下，在体内的作用，而不干扰其他外源性氧化还原剂（如促氧化剂或抗氧化剂）。MethodsWe发明了一种新的方法设置，利用大的氧化还原个体间的运动反应的变化。更具体地说，我们使用运动引起的氧化应激作为分类器的测量（即低，中，高），并调查了生理和氧化还原适应后，6周的耐力训练protocol.ResultsWe表明，与低运动诱导的氧化应激组表现出最低的改善，在电池的经典适应耐力训练（最大摄氧量、时间试验和Wingate试验）以及一组氧化还原生物标志物（氧化应激生物标志物和抗氧化剂），与高和中等氧化应激组相比，结论这项研究的发现证实，第一次在人类体内生理环境中，并且在没有任何外源性氧化还原操纵的情况下，运动过程中产生的RONS在适应中的重要作用。分层的方法，基于氧化还原表型，在这项研究中实施可能是一个有用的实验策略，揭示RONS和抗氧化剂在其他生物学表现的作用。
AimThe aim of this study was to reveal the role of reactive oxygen and nitrogen species (RONS) in exercise adaptations under physiological in vivo conditions and without the interference from other exogenous redox agents (e.g. a pro-oxidant or antioxidant).MethodsWe invented a novel methodological set-up that exploited the large redox interindividual variability in exercise responses. More specifically, we used exercise-induced oxidative stress as the classifier' measure (i.e. low, moderate and high) and investigated the physiological and redox adaptations after a 6-week endurance training protocol.ResultsWe demonstrated that the group with the low exercise-induced oxidative stress exhibited the lowest improvements in a battery of classic adaptations to endurance training (VO2 max, time trial and Wingate test) as well as in a set of redox biomarkers (oxidative stress biomarkers and antioxidants), compared to the high and moderate oxidative stress groups.ConclusionThe findings of this study substantiate, for the first time in a human in vivo physiological context, and in the absence of any exogenous redox manipulation, the vital role of RONS produced during exercise in adaptations. The stratification approach, based on a redox phenotype, implemented in this study could be a useful experimental strategy to reveal the role of RONS and antioxidants in other biological manifestations as well.