Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women
Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women
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DOI：
10.1038/sj.npp.1301042
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发表时间：
2006-09-01
影响因子：
7.6
通讯作者：
Newhouse, Paul
中科院分区：
文献类型：
--
作者：
Dumas, Julie;Hancur-Bucci, Catherine;Newhouse, Paul
在动物模型中，雌激素已被证明与胆碱能系统相互作用并影响认知。本研究探讨了雌激素和胆碱能系统功能的相互作用和这种相互作用对健康老年女性认知任务的影响。15名绝经后妇女被随机盲法给予1 mg 17-β雌二醇或安慰剂3个月，之后她们参加了5次抗胆碱能激发会议，在那里她们被给予两种剂量的抗毒蕈碱药物东莨菪碱（SCOP）或抗尼古丁药物美加明（MECA）或安慰剂之一。在第一次激发阶段后，将它们交叉到另一种激素治疗中再持续3个月，并重复激发。在抗胆碱能药物激发过程中，评估了多个认知领域的表现，包括注意力以及言语和非言语学习和记忆。结果表明，雌激素预处理减轻了抗胆碱能药物引起的注意和速度任务测试的损害。这项研究首次证明了雌激素和胆碱能系统的相互作用以及对人类认知能力的影响。结果表明，雌激素状态可能会影响胆碱能系统的张力，并可能是重要的胆碱能系统的完整性。
Estrogen has been shown to interact with the cholinergic system and influence cognition in animal models. This study investigated the interaction of estrogen and cholinergic system functioning and the effects of this interaction on cognitive task performance in healthy older women. Fifteen post-menopausal women were randomly and blindly placed on 1mg of 17-beta estradiol or placebo for 3 months after which they participated in five anticholinergic challenge sessions, where they were administered one of two doses of the antimuscarinic drug scopolamine (SCOP) or the antinicotinic drug mecamylamine (MECA) or placebo. After the first challenge phase, they were crossed over to the other hormone treatment for another 3 months and repeated the challenges. Performance in multiple domains of cognition was assessed during anticholinergic drug challenge, including attention and verbal and nonverbal learning and memory. Results showed that estrogen pretreatment attenuated the anticholinergic drug-induced impairments on tests of attention and tasks with speed components. This study is the first to demonstrate the interaction of estrogen and the cholinergic system and the effects on cognitive performance in humans. The results suggest that estrogen status may affect cholinergic system tone and may be important for cholinergic system integrity.