The Severity of Takayasu Arteritis Is Associated with the HLA-B52 Allele in Japanese Patients.
The Severity of Takayasu Arteritis Is Associated with the HLA-B52 Allele in Japanese Patients.
复制标题
日本患者高安动脉炎的严重程度与 HLA-B52 等位基因有关。
DOI：
10.1620/tjem.239.67
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发表时间：
2016
影响因子：
2.2
通讯作者：
A. Kawakami
中科院分区：
文献类型：
--
作者：
T. Origuchi;S. Fukui;M. Umeda;A. Nishino;Y. Nakashima;T. Koga;S. Kawashiri;N. Iwamoto;K. Ichinose;M. Tamai;Hideki Nakamura;A. Kawakami
大动脉炎（TA）是一种血管炎，影响大的弹性动脉，特别是主动脉及其主要分支。据报道，TA最常发生在日本西部地区的长崎县。我们回顾性收集了2003年至2015年长崎大学医院病历中使用美国流变学会1990年TA分类标准诊断的34例TA患者的信息，并调查了这些TA患者的临床特征。在35例患者中，25例患者进行了检查的HLA-B52等位基因的存在，已报告影响TA的易感性。HLA-B52-等位基因阳性者17例（68.0%）。吸烟者的比例有显著差异：HLA-B52等位基因阳性：6例（35.3%）与HLA-B52等位基因阴性：0例（0.0%）。HLA-B_（52）阳性患者C反应蛋白水平（9.0 ± 6.4）mg/dL显著高于HLA-B_（52）阴性患者（3.2 ± 3.9）mg/dL。所有HLA-B52等位基因阳性的患者被发现是活跃的根据克尔的标准。HLA-B52阳性患者的泼尼松龙初始剂量（37.7 ± 8.6 mg/d）显著高于HLA-B52阴性患者（23.1 ± 13.1 mg/d）。因此，HLA-B52等位基因与TA患者的疾病活动和类固醇需求相关。此外，我们目前的研究结果首次揭示了HLA-B52等位基因和吸烟可能与TA的发病。
Takayasu arteritis (TA) is a type of vasculitis that affects the large elastic arteries, specifically the aorta and its main branches. It has been reported that TA occurred most frequently in Nagasaki Prefecture, the western area in Japan. We retrospectively collected the information of 34 patients with TA, diagnosed using the American College of Rheumatology 1990 criteria for the classification of TA, from the medical records of Nagasaki University Hospital from 2003 to 2015, and we investigated the clinical characteristics of these TA patients. Among the 35 patients, 25 patients were examined for the existence of the HLA-B52 allele that has been reported to influence TA susceptibility. Seventeen patients (68.0%) of the 25 patients were HLA-B52-allele-positive, which was defined as the state of having at least one HLA-B52 allele. There was a significant difference in the rate of smokers: HLA-B52-allele-positive: six patients (35.3%) vs. HLA-B52-allele-negative: 0 (0.0%). The C-reactive protein level in the HLA-B52-positive patients (9.0 ± 6.4 mg/dL) was significantly higher than that in the HLA-B52-negative patients (3.2 ± 3.9 mg/dL). All HLA-B52-allele-positive patients were found to be active according to Kerr's criteria. The HLA-B52-positive patients' initial prednisolone dosage (37.7 ± 8.6 mg/day) was significantly higher than that of the HLA-B52-allele-negative patients (23.1 ± 13.1 mg/day). Thus, the HLA-B52 allele is associated with the disease activity and the steroid requirements of TA patients. Furthermore, our present findings have revealed for the first time that the HLA-B52 allele and smoking might be associated with the onset of TA.