Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index.
Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index.
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DOI：
10.1371/journal.pone.0169938
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Husain M
中科院分区：
文献类型：
--
作者：
Ang YS;Lockwood P;Apps MA;Muhammed K;Husain M
冷漠是一种使人衰弱但知之甚少的疾病，其特征是动机减少。除了与几种大脑疾病有关外，冷漠在健康人群中也不同程度地普遍存在。虽然已经开发了许多工具来评估临床疾病中的冷漠程度，但令人惊讶的是，没有适合健康人的冷漠措施。此外，尽管冷漠通常与抑郁、快感缺乏和疲劳的症状共病，但这些症状如何以及为什么相关尚不清楚。在这里，我们开发了冷漠动机指数（AMI），一个简短的冷漠和动机的自我报告指数。使用探索性因素分析（在505人的样本中），然后验证性分析（在479人的不同集合中），我们确定了行为，社会和情感领域的冷漠亚型。潜在的个人资料分析表明，四个不同的配置文件的冷漠，与不同程度的抑郁症，快感缺乏和疲劳。AMI是一种新的和可靠的措施，冷漠的个体差异，并可能提供一个有用的手段，探索不同的机制，亚临床缺乏动机，否则健康的个人。此外，冷漠和共病状态之间的关联可能反映了不同情感，社会和行为领域的问题。
Apathy is a debilitating but poorly understood disorder characterized by a reduction in motivation. As well as being associated with several brain disorders, apathy is also prevalent in varying degrees in healthy people. Whilst many tools have been developed to assess levels of apathy in clinical disorders, surprisingly there are no measures of apathy suitable for healthy people. Moreover, although apathy is commonly comorbid with symptoms of depression, anhedonia and fatigue, how and why these symptoms are associated is unclear. Here we developed the Apathy-Motivation Index (AMI), a brief self-report index of apathy and motivation. Using exploratory factor analysis (in a sample of 505 people), and then confirmatory analysis (in a different set of 479 individuals), we identified subtypes of apathy in behavioural, social and emotional domains. Latent profile analyses showed four different profiles of apathy that were associated with varying levels of depression, anhedonia and fatigue. The AMI is a novel and reliable measure of individual differences in apathy and might provide a useful means of probing different mechanisms underlying sub-clinical lack of motivation in otherwise healthy individuals. Moreover, associations between apathy and comorbid states may be reflective of problems in different emotional, social and behavioural domains.