Maternal deprivation of neonatal rats produces enduring changes in dopamine function
Maternal deprivation of neonatal rats produces enduring changes in dopamine function
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DOI：
10.1002/(sici)1098-2396(199904)32:1
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发表时间：
1999-04
期刊：
影响因子：
2.3
通讯作者：
F. Hall;F. Hall;L. Wilkinson;T. Humby;T. Robbins
中科院分区：
文献类型：
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作者：
F. Hall;F. Hall;L. Wilkinson;T. Humby;T. Robbins
隔离饲养断奶大鼠产生行为和神经化学效应综合征，表明成年期腹侧纹状体多巴胺功能增强。相比之下，母亲剥夺新生大鼠减少行为反应多巴胺激动剂在成年人中进行测试时，这可能表明相反的情况。然而，在本研究中，据报道，在体内微透析的延髓核（NAC）显示，增加释放多巴胺（DA）的反应，d-安非他明和高K+灌注液在母体剥夺的主题。因此，尽管NAC的突触前多巴胺能功能明显增加，但在母性剥夺的大鼠中，对d-苯丙胺的行为反应会减弱。Synapse 32：37-43，1999.© 1999 Wiley利斯公司
Isolation‐rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in adults, which may indicate the opposite situation. However, in the present study it is reported that in vivo microdialysis of the nucleus accumbens (NAC) revealed enhanced release of dopamine (DA) in response to both d‐amphetamine and high K+ perfusate in maternally deprived subjects. Thus, behavioral responses to d‐amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC. Synapse 32:37–43, 1999. © 1999 Wiley‐Liss, Inc.