Neural correlates of glucocorticoids effects on autobiographical memory retrieval in healthy women
Neural correlates of glucocorticoids effects on autobiographical memory retrieval in healthy women
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DOI：
10.1016/j.bbr.2018.06.024
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发表时间：
2019-02-01
影响因子：
2.7
通讯作者：
Wingenfeld, Katja
中科院分区：
文献类型：
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作者：
Fleischer, Juliane;Metz, Sophie;Wingenfeld, Katja
众所周知，应激后或外源性给药后皮质醇的升高会损害情景记忆提取，包括自传体记忆(AM)提取。这种损伤可能是由与记忆提取相关的神经网络失活所介导的，该神经网络包括前额叶皮质(PFC)和边缘结构。然而，这些皮质醇对AM恢复的影响的神经基础还没有被研究。在这项研究中，33名健康女性在完成功能磁共振期间的AM测试之前，以双盲交叉设计接受了安慰剂或10毫克氢化可的松。在这项测试中，参与者被要求回忆他们自己过去的特定事件，以回应一个提示词。在第一步，我们分析了在安慰剂条件下AM提取的神经基础。我们发现了一个与自传体记忆回忆相关的核心区域的激活模式，这些区域包括腹内侧PFC、前内侧(AM)PFC、额叶下回、后扣带回、顶叶交界处、颞中回和海马体。此外，我们分析了氢化可的松与安慰剂在AM恢复过程中的脑激活情况。感兴趣区(ROI)分析显示，在右侧AMPFC的AM重现过程中，氢化可的松导致失活。在AM提取过程中，氢化可的松对AMPFC的影响最为显著。这可能是因为这个大脑区域强烈地参与了自我参照行为，而自我参照行为是回忆自传信息的关键。
It is well known that elevated cortisol after stress or after exogenous administration impairs episodic memory retrieval including autobiographical memory (AM) retrieval. This impairment might be mediated by deactivation of a neural network associated with memory retrieval including the prefrontal cortex (PFC) and limbic structures. However, the neural underpinnings of these cortisol effects on AM retrieval have not been investigated yet.In this study, thirty-three healthy women received either placebo or 10 mg hydrocortisone in a double blind cross-over design before completing an AM test during fMRI. In this test, participants are asked to recall specific events from their own past in response to a cue word.In a first step, we analyzed the neural underpinnings of AM retrieval in the placebo condition. We found an activation pattern consistent with core regions involved in autobiographical memory recall, including the ventromedial PFC, anterior medial (am)PFC, inferior frontal gyms, the posterior cingulate cortex, the tempoparietal junction, the middle temporal gyms and the hippocampus. Further, we analyzed brain activation during AM retrieval after hydrocortisone compared to placebo. Region of interest (ROI) analyses revealed a hydrocortisone-induced deactivation during AM retrieval in the right amPFC. Results of the ROI analyses were nonsignificant in the left and right hippocampus, the left and right vmPFC and the left amPFCIn sum, during AM retrieval hydrocortisone had the most pronounced effects on the amPFC. This might be explained by the strong involvement of this brain region in self-referential behavior, which is essential for recalling autobiographic information.