African-American HLA class II allele and haplotype diversity.
African-American HLA class II allele and haplotype diversity.
复制标题
非裔美国人 HLA II 类等位基因和单倍型多样性。
DOI：
10.1111/j.1399-0039.1996.tb02686.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Klitz,W
中科院分区：
文献类型：
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作者：
Just,JJ;King,MC;Thomson,G;Klitz,W
使用分子遗传学技术对来自纽约市（NYC）的241名无关非裔美国人的HLA II类区域中的9个基因座进行分型。最近的遗传混合物的几个影响是明显的：不同的II类等位基因和单倍型的数量在非洲裔美国人比非洲或欧洲血统的人更大，等位基因频率更一致，连锁不平衡存在于整个II类地区。非裔美国人的DRB 1等位基因频率几乎总是落在来自北方欧洲和冈比亚的样本之间，这两个可能的创始人群。这些例外是由于其他基因不同的非洲群体对非洲裔美国人基因库的贡献。DRB 1等位基因频率（特别是DRB 1*1501）和DRB 1-DPB 1的一些单倍型在我们的纽约和第11届国际组织相容性研讨会（IHW）的非裔美国人样本中是不同的。在非裔美国人中发现的高水平的等位基因和单倍型多样性对于构建用于组织移植的无关潜在供体库具有重要意义。
Molecular genetic techniques were used to type nine loci in the HLA class II region in 241 unrelated African‐Americans from New York City (NYC). Several effects attributable to recent genetic admixture were evident: the number of distinct class II alleles and haplotypes was larger in the African‐Americans than in people of African or European origin, the allele frequencies were more consistently even, and linkage disequilibrium was present across the entire class II region. The African‐American DRB1 allele frequencies almost always fell between frequencies among samples from northern Europe and the Gambia, two possible founding populations. The exceptions are attributed to the contribution of other genetically dissimilar African groups to the African‐American gene pool. DRB1 allele frequencies (specifically DRB 1*1501) and some haplotypes of DRB 1‐DPB1 were different in our NYC and the 11th International Histocompatibility Workshop (IHW) samples of African‐Americans. The high level of allele and haplotype diversity found in African‐Americans has important implications for the construction of pools of unrelated potential donors for tissue transplantation.