Lipidomics reveals early markers.
Lipidomics reveals early markers.
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DOI：
10.1038/s41574-021-00572-4
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发表时间：
2021-12-01
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影响因子：
--
通讯作者：
Greenhill, Claire
中科院分区：
文献类型：
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作者：
Greenhill, Claire
发表在《自然代谢》杂志上的一项新研究表明，肝细胞分泌的外泌体根据肥胖的阶段有不同的作用。在早期肥胖小鼠（喂食高脂肪饮食4周）中，外泌体被证明可以提高胰岛素效率。作者发现这种有益作用是由miR-3075介导的，miR-3075在外泌体中富集。相比之下，在慢性肥胖小鼠（喂食高脂肪饮食16-18周）中，外泌体促进巨噬细胞的促炎激活，导致胰岛素抵抗。这些外泌体具有高水平的miR-434-3p，可促进巨噬细胞向m1样状态极化。作者认为miR-3075可能对人类具有胰岛素增敏作用，但这需要进一步研究。此外，靶向miR-434-3p可能被证明是有益的。
New research published in Nature Metabolism shows that exosomes secreted from hepatocytes have different effects depending on the stage of obesity. In early obesity (mice fed a high-fat diet for 4 weeks), the exosomes were shown to enhance insulin efficiency. The authors found that this beneficial effect was mediated by miR-3075, which was enriched in the exosomes. By contrast, in mice with chronic obesity (fed a high-fat diet for 16–18 weeks), the exosomes promoted proinflammatory activation of macrophages, which resulted in insulin resistance. These exosomes had high levels of miR-434-3p, which promotes polarization of macrophages towards an M1-like state. The authors suggest that miR-3075 could have insulin-sensitizing effects in humans, but this needs to be investigated further. In addition, targeting miR-434-3p could prove to be beneficial.