Adenovirus-mediated gene delivery to dendritic cells.
Adenovirus-mediated gene delivery to dendritic cells.
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腺病毒介导的基因递送至树突状细胞。
作者：
L. Timares;J. T. Douglas;Bryan W. Tillman;V. Krasnykh;D. Curiel
树突状细胞(DC)是一种“专业的”抗原提呈细胞(APC)，具有激活和引导幼稚免疫系统产生特定细胞和体液反应的独特能力。对这一关键功能的认识使以DC为基础的免疫疗法技术的开发成为治疗各种疾病的优先事项。这项新兴技术最直接的影响将是癌症的治疗和第三代疫苗的开发，以防止病毒和细胞内病原体。除了激发免疫反应外，树突状细胞还能维持对“自我”的耐受性。一旦了解了这一重要功能的生物学基础，基于DC的免疫疗法的未来应用可能会被开发出来，以改善自身免疫性疾病或提高对移植器官的接受度。通过体外方法的最新进展，实现了DC功能工程的可行性，这些方法允许选择性地在体外繁殖DC、抗原负载和基因修饰，以便随后将治疗性转移到宿主体内。最终，对这些细胞进行基因修饰的能力将使我们能够设计DC介导的干预措施，指导体内对免疫激活或耐受的可预测控制。
Dendritic cells (DCs) are "professional" antigen-presenting cells (APCs) that are uniquely capable of activating and instructing a naive immune system to mount a specific cellular and humoral response. Recognition of this crucial function makes the development of technologies for DC-based immuno-therapies a priority for the treatment of a wide variety of diseases. The most immediate impact of this emerging technology will be in the treatment of cancer and the development of third generation vaccines to protect against viral and intracellular pathogens. In addition to elicitation of immune responses, DCs also function to maintain tolerance to "self." Once the biological basis for this important function is understood, future applications of DC-based immuotherapies may be developed to ameliorate autoimmune diseases or enhance acceptance of transplanted organs. The feasibility of "engineering" the function of DCs has been realized by recent advances in ex vivo methodologies that allow selective DC propagation, antigen loading, and genetic modification in vitro for subsequent therapeutic transfer into the host. Ultimately, the ability to genetically modify these cells will allow us to design DC-mediated interventions that will direct predictable control of either immune activation or tolerance in vivo.
从鼠表皮连续产生抗原呈递树突状细胞系。
DOI：
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发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Xu,S;Ariizumi,K;Caceres-Dittmar,G;Edelbaum,D;Hashimoto,K;Bergstresser,PR;Takashima,A
通讯作者：
Takashima,A
在小鼠模型中，针对 CD40 的腺病毒载体增强了基于树突状细胞的疫苗接种针对人乳头瘤病毒 16 诱导的肿瘤细胞的功效。
影响因子：
11.2
作者：
Tillman,BW;Hayes,TL;DeGruijl,TD;Douglas,JT;Curiel,DT
通讯作者：
Curiel,DT