A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis
A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis
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DOI：
10.1016/j.humpath.2006.06.010
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发表时间：
2007-01-01
期刊：
影响因子：
3.3
通讯作者：
Sugano, Kentaro
中科院分区：
文献类型：
--
作者：
Sakamoto, Hirotsugu;Mutoh, Hiroyuki;Sugano, Kentaro
我们先前曾报告一例人类胆囊胆石症的肠上皮化生与尾相关的同源异型盒转录因子（Cdx 2）的表达。然而，目前尚不清楚肠上皮化生和Cdx 2表达在人类非肿瘤性胆囊结石中的发生频率。我们研究了胆石症患者胆囊肠上皮化生的发生率和Cdx 2的表达。2003年9月至2005年3月期间，对103例胆石症患者进行了腹腔镜胆囊切除术。患者的平均年龄为59.6 ± 15.0岁（范围：22-92岁）。我们对这些病例进行回顾性分析，以寻找肠上皮化生的存在和Cdx 2的表达。此外，肠上皮化生的特点进行了检查，免疫组化Muc 2，嗜铬粒蛋白A，和5-羟色胺。胆石症患者中肠上皮化生发生率为11.7%（12/103）。有肠上皮化生和无肠上皮化生患者的平均年龄分别为60.8 ± 15.4岁和59.4 ± 14.9岁。Cdx 2、Muc 2、嗜铬粒蛋白A和5-羟色胺在肠化生粘膜中的表达率分别为91.7%（11/12）、91.7%（11/12）、83.3%（10/12）和50.0%（6/12）。只有1例（1.1%）表达Cdx 2而无肠上皮化生的患者不表达Muc 2、嗜铬粒蛋白A和5-羟色胺。我们发现，10.7%（11/103）的非肿瘤性胆囊切除术，因为胆囊结石腹腔镜下发现肠上皮化生与Cdx 2表达。(c)2007爱思唯尔公司All rights reserved.
We previously reported a case of a human gallbladder with cholelithiasis consisting of intestinal metaplasia with the expression of caudal-related homeobox transcription factor (Cdx2). However, it is unclear how often intestinal metaplasia and Cdx2 expression occur in human, nontumorous gallbladders with cholelithiasis. We studied the incidence of intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis. Gallbladders were resected under laparoscopy from 103 patients with cholelithiasis between September 2003 and March 2005. The mean age of the patients was 59.6 +/- 15.0 years (range, 22-92 years). We retrospectively reviewed these cases to look for the presence of intestinal metaplasia and the expression of Cdx2. In addition, the characteristics of intestinal metaplasia were examined by immunostaining for Muc2, chromogranin A, and serotonin. Intestinal metaplasia was found in 11.7% (12/103) of the gallbladders with cholelithiasis. The mean ages of patients with and without intestinal metaplasia were 60.8 +/- 15.4 and 59.4 +/- 14.9 years, respectively. Cdx2, Muc2, chromogranin A, and serotonin were expressed in 91.7% (11/12), 91.7% (11/12), 83.3% (10/12), and 50.0% (6/12) in intestinal metaplastic mucosa, respectively. Only one case (1.1%) that expressed Cdx2 without intestinal metaplasia did not express Muc2, chromogranin A, and serotonin. We found that 10.7% (11/103) of nontumorous gallbladders resected because of cholelithiasis under laparoscopy revealed intestinal metaplasia with Cdx2 expression. (c) 2007 Elsevier Inc. All rights reserved.