Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study.
Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study.
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DOI：
10.1016/j.jes.2022.01.017
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发表时间：
2022-01
影响因子：
6.9
通讯作者：
Bing Yue;Shang-xia Ning;H. Miao;C. Fang;Jingguang Li;Lei Zhang;Yan Bao;S. Fan;Yun-feng Zhao;Yongning Wu
中科院分区：
文献类型：
--
作者：
Bing Yue;Shang-xia Ning;H. Miao;C. Fang;Jingguang Li;Lei Zhang;Yan Bao;S. Fan;Yun-feng Zhao;Yongning Wu
暴露于内分泌干扰物（EDCs）可能会破坏甲状腺激素的稳态。然而，人类流行病学研究报告的观察结果不一致，关于化学品混合物影响的资料很少。本研究的目的是探讨多种化学物质与甲状腺激素的关系，从中国成年人。我们测量了177名无职业暴露的健康成年人的血清甲状腺激素水平和11种内分泌干扰物的尿液水平，包括6种邻苯二甲酸酯代谢物、双酚A（BPA）、双酚F（BPF）、双酚S（BPS）、高氯酸盐和硫氰酸盐。通过一般线性回归分析和baker-kernal机回归分析来检查多种尿液分析物与血清甲状腺激素的关联。这些内分泌干扰物在几乎所有的样品中都被检测到。在调整各种协变量后，我们观察到只有BPF与总甲状腺素（TT 4）显著相关。（β=-0.27，95%置信区间（CI）[-0.41，-0.14]），总三碘甲状腺原氨酸（TT 3）（β=-0.02 95% CI [-0.03，-0.01]），游离T4（fT 4）（β=-0.02，95% CI [-0.03，-0.01]）和游离T3（fT 3）（β=-0.04，95% CI [-0.07，-0.01]），单-邻苯二甲酸（2-乙基-5-氧代己基）酯（MEOHP）和邻苯二甲酸单乙酯（MEP）与TT 4正相关（β=0.24，95% CI [0.01，0.48]）和fT4（β=0.02，95% CI [0.01，0.04]）。此外，我们观察到TT 4与11种内分泌干扰物的混合物之间存在显著的剂量-反应关系，BPF是混合效应的主要贡献者，这表明在人体暴露于多种内分泌干扰物的真实的场景下，BPF对甲状腺功能的潜在影响优先。我们的研究结果支持了这一假设，即人类暴露于低水平的内分泌干扰物可以改变甲状腺激素的稳态在非职业健康成人。
Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and urinary levels of 11 EDCs, including six phthalate metabolites, bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), perchlorate, and thiocyanate among 177 healthy adults without occupational exposure. Associations of multiple urinary analytes with serum thyroid hormones were examined by performing general linear regression analysis and bayesian kernal machine regression analysis. These EDCs were detected in almost all samples. After adjusting for various covariates, we observed only BPF significantly associated with total thyroxin (TT4) (β=-0.27, 95% confidence interval (CI) [-0.41, -0.14]), total triiodothyronine (TT3) (β=-0.02 95% CI [-0.03, -0.01]), free T4 (fT4) (β=-0.02, 95% CI [-0.03, -0.01]), and free T3 (fT3) (β=-0.04, 95% CI [-0.07, -0.01]), and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and monoethyl phthalate (MEP) positively associated with TT4 (β=0.24, 95% CI [0.01, 0.48]) and fT4 (β=0.02, 95% CI [0.01, 0.04]), respectively. Moreover, we observed significant dose-response relationships between TT4 and the mixture of 11 EDCs, and BPF was the main contributor to the mixture effect, suggesting the priority of potential effect of BPF on disrupting thyroid function under a real scenario of human exposure to multiple EDCs. Our findings supported the hypothesis that human exposure to low levels of EDCs could alter thyroid hormones homeostasis among non-occupational healthy adults.