Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients
Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients
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DOI：
10.1016/j.euroneuro.2006.04.010
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发表时间：
2006-12-01
影响因子：
5.6
通讯作者：
Gennarelli, Massimo
中科院分区：
文献类型：
--
作者：
Bocchio-Chiavetto, Luisella;Zanardini, Roberta;Gennarelli, Massimo
一些研究结果表明，神经营养因子BDNF可能有助于抗抑郁治疗的临床疗效。本研究的目的是分析ECT是否对耐药抑郁症患者的血清BDNF水平有调节作用。结果显示ECT后血清BDNF水平显著升高。更具体地说，虽然整个样本在TO（基线）和T1（ECT后）之间没有发生变化（p=0.543），但在ECT结束后一个月的T2处发现了显着增加（p=0.002）。然而，即使在具有低基线BDNF水平的患者亚组中，BDNF增强在T0和T1之间也是明显的。尽管还需要进一步的研究，但本文的结果首次表明ECT与血清BDNF的变化相关，并进一步支持BDNF可能参与抗抑郁治疗。(c)2006 Elsevier B.V.和ECNR保留所有权利。
Several findings have suggested that the neurotrophin BDNF could contribute to clinical efficacy of antidepressant treatments. The purpose of this study was to analyse if ECT operates a modulation of serum BDNF levels in a sample of drug resistant depressed patients. The results obtained show significantly higher serum levels of BDNF following ECT. More specifically, while no change occurred in the whole sample between TO (baseline) and T1 (after ECT) (p=0.543) a significant increase has been identified at T2, one month after the end of ECT (p=0.002). However, the BDNF augmentation was evident even between TO and T1 in a subgroup of patients who has tow baseline BDNF levels. Although future researches are needed, the results herein presented show for the first time that ECT is associated with changes in serum BDNF and further support the possible involvement of BDNF in antidepressant therapies. (c) 2006 Elsevier B.V. and ECNR All rights reserved.