Histological heterogeneity in primary and metastatic classic combined hepatocellular-cholangiocarcinoma: a case series
Histological heterogeneity in primary and metastatic classic combined hepatocellular-cholangiocarcinoma: a case series
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DOI：
10.1007/s00428-017-2196-x
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发表时间：
2017-11-01
期刊：
影响因子：
3.5
通讯作者：
Quaglia, Alberto
中科院分区：
文献类型：
--
作者：
De Vito, Claudio;Sarker, Debashis;Quaglia, Alberto
联合性肝细胞胆管癌（cHCC-CC）是一种罕见的侵袭性原发性肝癌，具有肝细胞和胆管细胞分化。由于其双表型成分，cHCC-CC 是一种异质性肿瘤，转移性沉积物的组织病理学分析特征很少。在这项回顾性研究中，我们描述了四名患者，其中原发性和复发性和/或转移性肿瘤切除标本的组织学可用于比较和免疫组织化学表征。我们的研究表明，复发性或转移性沉积物复制了原发性 cHCC-CC 的异质性，即使最初分化分化的小病灶也可能在以后变得占主导地位，并且肝细胞和胆管细胞成分可以在远处器官中表现出不同的趋向性。根据我们的经验，复发/转移性 cHCC-CC 的行为是不可预测的，目前需要组织学检查来指导治疗选择。
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare and aggressive primary liver cancer with both hepatocellular and cholangiocellular differentiation. Due to its bi-phenotypic component, cHCC-CC is a heterogeneous tumour and histopathological analysis of metastatic deposits is poorly characterized. In this retrospective study, we describe four patients in whom the histology from resected specimens of both primary and recurrent and/or metastatic tumour was available for comparison and immunohistochemical characterization. Our study shows that recurrent or metastatic deposits replicate the heterogeneity of the primary cHCC-CC, that even originally small foci of divergent differentiation can become predominant later on and that hepatocellular and cholangiocellular components can show different tropism in distant organs. In our experience, the behaviour of recurrent/metastatic cHCC-CC is unpredictable and histological examination is necessary to guide treatment options at present.