The role of lactic acidosis in the ischemic nerve cell injury.
The role of lactic acidosis in the ischemic nerve cell injury.
复制标题
乳酸性酸中毒在缺血性神经细胞损伤中的作用。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
B. Söderfeldt
中科院分区：
文献类型：
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作者：
H. Kalimo;S. Rehncrona;B. Söderfeldt
采用夹紧颈动脉和降低血压的方法，诱导大鼠脑血流低于正常值5%，持续30 min的严重不完全性脑缺血。一组大鼠禁食（f-rats），另一组大鼠在诱导缺血前输注葡萄糖（g-rats）。在大鼠中，在大脑皮层中积累的乳酸约为15 μ mol。G-1，而g-大鼠则上升到35 μ mol。努力解决。在再循环过程中，f大鼠的能量状态和电活动出现了相当大的恢复，而g大鼠的能量衰竭持续存在，没有电活动再次出现。在f大鼠中，结构改变的严重程度较轻，但在g大鼠中，可以看到广泛的进行性组织损伤。提示组织乳酸酸中毒程度对不可逆缺血性神经细胞损伤的发生发展有显著影响。
Severe incomplete cerebral ischemia of 30 min duration with CBF below 5% of normal was induced in rats by clamping both carotids and lowering BP. One group of rats were fasting (f-rats), while the other was infused with glucose before induction of the ischemia (g-rats). In f-rats the lactate accumulating in the cerebral cortex was about 15 mumol . g-1, whereas in g-rats it rose to about 35 mumol . g-1. In f-rats considerable recovery of the energy state and electrical activity occurred during recirculation, whereas in g-rats the energy failure persisted with no electrical activity reappearing. In f-rats the structural alterations were of minor severity, but in g-rats extensive progressive tissue damage was seen. The data indicate that the degree of tissue lactic acidosis has pronounced effects on the development of irreversible ischemic nerve cells injury.