The relationship between incidence of fractures and anemia in older multiethnic women.
The relationship between incidence of fractures and anemia in older multiethnic women.
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DOI：
10.1111/j.1532-5415.2010.03183.x
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发表时间：
2010-12
影响因子：
6.3
通讯作者：
Short list of Women's Health Initiative Investigators
中科院分区：
文献类型：
--
作者：
Chen Z;Thomson CA;Aickin M;Nicholas JS;Van Wyck D;Lewis CE;Cauley JA;Bassford T;Short list of Women's Health Initiative Investigators
本研究的目的是前瞻性地研究贫血和髋关节，脊柱和所有骨骼部位的骨折事件之间的关系，在妇女的健康倡议（WHI）观察性研究和临床试验登记的不同种族和民族背景的妇女。前瞻性队列研究。美国40个WHI临床中心。绝经后妇女（n = 160，080），平均年龄63.2（SD：7.2）岁，被招募并随访平均7.8年。贫血定义为基线时血红蛋白水平低于12 g/dL。所有骨折均为自我报告。髋关节骨折由经过培训的医生使用病历进一步证实。在参与者中，8 739名妇女（5.5%）贫血。每10，000人年髋部骨折的年龄校正发病率在贫血女性中为21.4，在无贫血女性中为15.0;还观察到贫血女性的脊柱或所有骨折的发病率较高。在考克斯比例风险模型中纳入多个协变量后，如风险比所示，与贫血相关的骨折风险显著增加仍然存在（95%置信区间）与贫血相关的骨折为1.38（1.13-1.68）、1.30（1.09-1.55）和1.07（1.01-1.14）。在这些关系中没有发现显著的种族/民族差异。在多种族绝经后贫血妇女中观察到骨折风险显著增加。鉴于贫血在老年人群中的高患病率，更好地了解贫血与骨折风险之间的关系和机制非常重要。
The purpose of this study was to prospectively examine the relationship between anemia and incident fractures of the hip, spine and all skeletal sites in women from diverse racial and ethnic backgrounds enrolled in the Women's Health Initiative (WHI) Observational Study and Clinical Trials. Prospective cohort study. 40 WHI clinical centers across the US. Postmenopausal women (n = 160,080), mean age 63.2 (SD: 7.2) years, were recruited and followed for an average of 7.8 years. Anemia was defined as hemoglobin levels at baseline less than 12 g/dL. All fractures were self-reported. Hip fractures were further confirmed by trained physicians using medical records. Among the participants 8,739 women (5.5%) were anemic. The age-adjusted incidence rate of hip fractures per 10,000 person years were 21.4 in women with anemia and 15.0 in women without anemia; a higher incidence rate for spine or all fractures in anemic women was also observed. After multiple covariates were included in the Cox proportional hazards models, significant increased fracture risk associated with anemia still existed as demonstrated by the hazards ratios (95% confidence interval) of fractures associated with anemia being 1.38 (1.13–1.68), 1.30 (1.09–1.55) and 1.07 (1.01–1.14) for hip, spine and all-types respectively. No significant racial/ethnic difference was found in these relationships. A significantly increased fracture risk was observed in multi-ethnic postmenopausal women with anemia. Given the high prevalence of anemia in the elderly population, it is important to better understand the relationship and mechanisms linking anemia to fracture risk.
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影响因子：
6.3
作者：
LaCroix AZ;Lee JS;Wu L;Cauley JA;Shlipak MG;Ott SM;Robbins J;Curb JD;Leboff M;Bauer DC;Jackson RD;Kooperberg CL;Cummings SR;Women's Health Initiative Observational
通讯作者：
Women's Health Initiative Observational
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
4
作者：
Cesari, M;Pahor, M;Ferrucci, L
通讯作者：
Ferrucci, L
影响因子：
6.2
作者：
Cauley, Jane A.;Wu, LieLing;Robbins, John
通讯作者：
Robbins, John
影响因子：
2.8
作者：
Duh, Mei Sheng;Mody, Samir H.;Piech, Catherine Tak
通讯作者：
Piech, Catherine Tak