Raman and terahertz spectroscopical investigation of cocrystal formation process of piracetam and 3-hydroxybenzoic acid
Raman and terahertz spectroscopical investigation of cocrystal formation process of piracetam and 3-hydroxybenzoic acid
复制标题
吡拉西坦与3-羟基苯甲酸共晶形成过程的拉曼和太赫兹光谱研究
DOI：
10.1016/j.saa.2014.11.109
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发表时间：
2015-03-15
影响因子：
4.4
通讯作者：
Hong, Zhi
中科院分区：
文献类型：
--
作者：
Du, Yong;Zhang, Huili;Hong, Zhi
Cocrystallization can improve physical and chemical properties of active pharmaceutical ingredient, and this feature has great potential in pharmaceutical development. In this study, the cocrystal of piracetam and 3-hydroxybenzoic acid under grinding condition has been characterized by Raman and terahertz spectroscopical techniques. The major vibrational modes of individual starting components and cocrystal are obtained and assigned. Spectral results show that the vibrational modes of the coctystal are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman and THz spectra. The formation rate is pretty fast in first several 20 min grinding time, and then it becomes slow. After similar to 35 min, such process has been almost completed. These results offer us the unique means and benchmark for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic during cocrystal formation process in pharmaceutical fields. (C) 2014 Elsevier B.V. All rights reserved.
