The Systemic Effects of Endometriosis
The Systemic Effects of Endometriosis
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DOI：
10.1055/s-0037-1603582
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发表时间：
2017-05-01
影响因子：
2.7
通讯作者：
Taylor, Hugh S.
中科院分区：
文献类型：
--
作者：
Alderman, Myles H., III;Yoder, Nicole;Taylor, Hugh S.
子宫内膜异位症是一种由子宫内膜腺体和间质在异位位置的存在所定义的疾病。虽然最常见的症状是盆腔疼痛、痛经和不孕症，但子宫内膜异位症也会对多器官系统产生全身性影响。在这里，我们回顾了文献描述密切相关的合并症，包括心血管疾病、癌症、自身免疫性疾病、精神疾病和代谢/体重。我们研究了子宫内膜异位症可能导致这些系统性影响的病理生理学和假设机制；其机制包括细胞因子和微rna的产生以及干细胞的迁移和传播。子宫内膜异位症的广泛全身性影响以及相关的合并症在子宫内膜异位症患者的治疗中经常被忽视。提高认识可能导致更有效的治疗和预防。
Endometriosis is a condition defined by the presence of endometrial glands and stroma in ectopic locations. While the most commonly seen symptoms of the disease are pelvic pain, dysmenorrhea, and infertility, endometriosis has also systemic effects in multiple organ systems. Here, we review literature describing closely associated comorbidities including cardiovascular disease, cancers, autoimmune disease, psychiatric conditions, and metabolism/ body weight. We examine the pathophysiology and hypothesized mechanism by which endometriosis may lead to these systemic effects; mechanisms include cytokine and micro-RNA production as well as stem cell migration and dissemination. The broad systemic effects of endometriosis as well as correlated comorbidities are often overlooked in the treatment of patients with endometriosis. Increased awareness may lead to more effective treatment and prevention.