OBSERVATIONS ON SPONTANEOUS IMPROVEMENT IN PATIENTS WITH PODAGRA - IMPLICATIONS FOR THERAPEUTIC TRIALS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS
OBSERVATIONS ON SPONTANEOUS IMPROVEMENT IN PATIENTS WITH PODAGRA - IMPLICATIONS FOR THERAPEUTIC TRIALS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS
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DOI：
10.1111/j.1365-2125.1987.tb03132.x
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发表时间：
1987-07-01
影响因子：
3.4
通讯作者：
BUCHANAN, WW
中科院分区：
文献类型：
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作者：
BELLAMY, N;DOWNIE, WW;BUCHANAN, WW
1对11例足突患者的急性痛风性关节炎自然史进行了研究。2两名患者在第4天因严重持续疼痛退出研究。其余患者在第5天疼痛和第7天肿胀均有所改善。到第7天，7名患者的肌张力改善，但2名患者继续经历与试验入组时相同的不适。尽管有这些改善，但在研究期间仅3例患者注意到疼痛消退。3.这些数据表明，虽然大多数患者表现出自发改善，但如果不使用有效的非甾体类药物，7天内不太可能消退。急性痛风发作的自然史的记录可以帮助临床研究者解释非甾体类抗痛风药物的非对照评价结果。
1 The natural history of acute gouty arthritis was studied in 11 volunteers with podagra. 2 Two patients withdrew from the study on day 4 because of severe persistent pain. Of the remaining patients all showed some improvement in pain by day 5 and in swelling by day 7. Tenderness improved in seven patients by day 7 but two continued to experience the same amount of discomfort as at trial entry. In spite of these improvements only three patients noted resolution of their pain during the study period. 3. These data indicate that while the majority of patients show spontaneous improvement, resolution is unlikely over a period of 7 days without the use of effective non-steroidal antiinflammatory medication. 4 Documentation of the natural history of the acute gouty attack may assist clinical investigators in interpreting the results of uncontrolled evaluations of non-steroidal antiinflammatory drugs.