Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes.
Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes.
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Krüppel 样因子 10 (KLF10) 作为关键信号传导介质：在生理和病理生理过程中具有多种功能
DOI：
10.1016/j.gendis.2022.06.005
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发表时间：
2023-05
期刊：
影响因子：
6.8
通讯作者：
Guo, Liang
中科院分区：
文献类型：
--
作者：
Luo, Hong-Yang;Zhu, Jie-Ying;Chen, Min;Mu, Wang-Jing;Guo, Liang
Krüppel样因子10（KLF 10），又称TGFβ诱导型早期基因1（TIEG 1），最早在人类成骨细胞中发现。早期研究表明KLF 10在成骨分化中起重要作用。通过几十年的研究，人们发现KLF 10在许多不同的细胞类型中具有复杂的功能，其表达和功能受到多种方式的调节。KLF 10作为转化生长因子β（TGFβ）/SMAD信号的下游因子，参与肝脏和脂肪组织糖脂代谢、骨骼肌线粒体结构和功能的维持、细胞增殖和凋亡等多种生物学功能，并在非酒精性脂肪性肝炎（NASH）和肿瘤等多种疾病过程中发挥作用。此外，KLF 10在许多方面的调节和功能表现出性别依赖性差异。本文就KLF 10的生物学功能及其在疾病状态中的作用进行综述，以期为KLF 10的功能研究提供新的视角，并为以KLF 10为靶点的治疗策略提供新的思路。
Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different cell types, and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling, KLF10 is involved in various biological functions, including glucose and lipid metabolism in liver and adipose tissue, the maintenance of mitochondrial structure and function of the skeletal muscle, cell proliferation and apoptosis, and plays roles in multiple disease processes, such as nonalcoholic steatohepatitis (NASH) and tumor. Besides, KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review, the biological functions of KLF10 and its roles in disease states is updated and discussed, which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.
影响因子：
6.2
作者：
Hawse, John R.;Pitel, Kevin S.;Cicek, Muzaffer;Philbrick, Kenneth A.;Gingery, Anne;Peters, Kenneth D.;Syed, Farhan A.;Ingle, James N.;Suman, Vera J.;Iwaniec, Urszula T.;Turner, Russell T.;Spelsberg, Thomas C.;Subramaniam, Malayannan
通讯作者：
Subramaniam, Malayannan
影响因子：
7.3
作者：
Kim G;Gu MJ;Kim SJ;Ko KH;Kye YC;Kim CG;Cho JH;Lee WK;Song KD;Chu H;Park YM;Han SH;Yun CH
通讯作者：
Yun CH