Absence of Frequent Herpesvirus Transmission in a Nonhuman Primate Predator-Prey System in the Wild
Absence of Frequent Herpesvirus Transmission in a Nonhuman Primate Predator-Prey System in the Wild
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DOI：
10.1128/jvi.01104-13
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发表时间：
2013-10-01
影响因子：
5.4
通讯作者：
Ehlers, Bernhard
中科院分区：
文献类型：
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作者：
Murthy, Sripriya;Couacy-Hymann, Emmanuel;Ehlers, Bernhard
通过非人灵长类动物（NHP）传播进入人群的病毒的出现对人类健康构成了严重的潜在威胁，这主要与肉类贸易的增加有关。RNA病毒在灵长类物种间的传播似乎相对频繁。相比之下，DNA病毒似乎在很大程度上是宿主特异性的，表明传播潜力低。在此，我们使用灵长类动物捕食系统来研究疱疹病毒在野外不同灵长类动物之间传播的风险。该系统由西部黑猩猩（Pan troglodytes verus）及其主要猎物猴种（西部红疣猴、Piliocolobus badius badius）和次要猎物猴种（黑白白色疣猴、Colobus polykomos）组成。经常观察到NHP种属与多种β-和γ-疱疹病毒（包括新的巨细胞病毒和Rhadinoviruses）共感染。然而，尽管黑猩猩经常接触到被疱疹病毒感染的猴子猎物的血液、器官和骨头，但没有证据表明疱疹病毒会跨物种传播。这些发现表明，NHP β-和γ-疱疹病毒的种间传播在野外最多是一种罕见的事件。
Emergence of viruses into the human population by transmission from nonhuman primates (NHPs) represents a serious potential threat to human health that is primarily associated with the increased bushmeat trade. Transmission of RNA viruses across primate species appears to be relatively frequent. In contrast, DNA viruses appear to be largely host specific, suggesting low transmission potential. Herein, we use a primate predator-prey system to study the risk of herpesvirus transmission between different primate species in the wild. The system was comprised of western chimpanzees (Pan troglodytes verus) and their primary (western red colobus, Piliocolobus badius badius) and secondary (black-and-white colobus, Colobus polykomos) prey monkey species. NHP species were frequently observed to be coinfected with multiple beta- and gammaherpesviruses (including new cytomegalo- and rhadinoviruses). However, despite frequent exposure of chimpanzees to blood, organs, and bones of their herpesvirus-infected monkey prey, there was no evidence for cross-species herpesvirus transmission. These findings suggest that interspecies transmission of NHP beta- and gammaherpesviruses is, at most, a rare event in the wild.