Effect of Paternal Age on Reproductive Outcomes of Intracytoplasmic Sperm Injection.
Effect of Paternal Age on Reproductive Outcomes of Intracytoplasmic Sperm Injection.
复制标题
父亲年龄对胞浆内单精子注射生殖结果的影响
DOI：
10.1371/journal.pone.0149867
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Wu Y;Kang X;Zheng H;Liu H;Huang Q;Liu J
父亲年龄对生殖的影响，特别是使用辅助生殖技术，迄今尚未得到充分研究。为了研究父亲年龄对生殖结局的影响，我们对2007年1月至2015年5月在广州医科大学第三附属医院生殖医学中心进行的2，627个卵胞浆内单精子注射（ICSI）周期进行了回顾性分析。通过多元线性回归分析了父本年龄对胚胎质量[受精卵数、2个原核合子（2 PN）数、存活胚胎数和高质量胚胎数]的影响。父亲年龄与妊娠结局的关系采用二元Logistic回归分析。在调整女性年龄后，没有观察到父亲年龄与以下胚胎质量参数之间的关联：（B = -0.032; 95% CI -0.069-0.005; P = 0.088），2个PN的数量（B = -0.005; 95% CI -0.044-0.034; P = 0.806）和存活胚胎数（B = -0.025; 95% CI -0.052-0.001; P = 0.062）。然而，父亲年龄对高质量胚胎的数量有负面影响（B = -0.020; 95% CI -0.040-0.000; P = 0.045）。此外，父亲年龄对妊娠结局没有影响（OR为5年间隔），包括临床妊娠率（OR 0.919; 95% CI 0.839-1.006; P = 0.067），持续妊娠（OR 0.914; 95% CI 0.833-1.003; P = 0.058），早期妊娠丢失（OR 1.019; 95% CI 0.823-1.263; P = 0.861）、活产（OR 0.916; 95% CI 0.833-1.007; P = 0.070）和早产（OR 1.061; 95% CI 0.898-1.254; P = 0.485）。因此，父亲年龄的增加会对高质量胚胎的数量产生负面影响，但对接受ICSI周期的夫妇的妊娠结局没有影响。然而，需要更多的研究，包括60岁以上的男性，并进行长期随访。
The impact of paternal age on reproduction, especially using assisted reproductive technologies, has not been well studied to date. To investigate the effect of paternal age on reproductive outcomes, here we performed a retrospective analysis of 2,627 intracytoplasmic sperm injection (ICSI) cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Guangzhou Medical University (China) between January 2007 and May 2015. Effect of paternal age on embryo quality [number of fertilized oocytes, 2 pronucleus zygotes (2PNs), viable embryos, and high-quality embryos] was analyzed by multiple linear regression. Relationships between paternal age and pregnancy outcomes were analyzed by binary logistic regression. After adjusting for female age, no association between paternal age and the following parameters of embryo quality was observed: number of fertilized oocytes (B = -0.032; 95% CI -0.069–0.005; P = 0.088), number of 2PNs (B = -0.005; 95% CI -0.044–0.034; P = 0.806), and number of viable embryos (B = -0.025; 95% CI -0.052–0.001; P = 0.062). However, paternal age negatively influenced the number of high-quality embryos (B = -0.020; 95% CI -0.040–0.000; P = 0.045). Moreover, paternal age had no effect on pregnancy outcomes (OR for a 5-year interval), including the rates of clinical pregnancy (OR 0.919; 95% CI 0.839–1.006; P = 0.067), ongoing pregnancy (OR 0.914; 95% CI 0.833–1.003; P = 0.058), early pregnancy loss (OR 1.019; 95% CI 0.823–1.263; P = 0.861), live births (OR 0.916; 95% CI 0.833–1.007; P = 0.070), and preterm births (OR 1.061; 95% CI 0.898–1.254; P = 0.485). Therefore, increased paternal age negatively influences the number of high-quality embryos, but has no effect on pregnancy outcomes in couples undergoing ICSI cycles. However, more studies including men aged over 60 years with a longer-term follow-up are needed.