Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia.
Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia.
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DOI：
10.1016/0304-3835(92)90071-3
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发表时间：
1992-06
期刊：
影响因子：
9.7
通讯作者：
Mou-tuan Huang;Eleanor E. Deschner;H. Newmark;Z. Y. Wang;Thomas Ferraro;Allan H. Conney
中科院分区：
文献类型：
--
作者：
Mou-tuan Huang;Eleanor E. Deschner;H. Newmark;Z. Y. Wang;Thomas Ferraro;Allan H. Conney
姜黄素，姜黄的一种主要黄色色素，从植物姜黄（Curcuma longa Linn.）通常用作食品、药品和化妆品的着色剂。抗坏血酸棕榈酸酯是抗坏血酸的脂溶性衍生物。姜黄素和抗坏血酸棕榈酸酯都具有抗氧化活性，并且是12-O-十四酰基-佛波醇-13-乙酸酯诱导的小鼠皮肤肿瘤促进的有效抑制剂。在喂食AIN 76 A饮食的雌性CF-1小鼠中评价饮食姜黄素和抗坏血酸棕榈酸酯对氧化偶氮甲醇（AOM）诱导的结肠上皮细胞过度增殖和异型增生灶性区域（FAD）发生率的影响。皮下注射AOM（10 mg/kg体重），每周一次，持续6周）引起结肠增生和FAD的形成。在饮食中给予2%姜黄素抑制AOM诱导的FAD形成，而在饮食中给予2%抗坏血酸棕榈酸酯没有表现出抑制作用。这一结果表明，饮食姜黄素可以抑制AOM诱导的小鼠结肠肿瘤。
Curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant Curcuma longa Linn., is commonly used as a coloring agent in foods, drugs and cosmetics. Ascorbyl palmitate is a lipid soluble derivative of ascorbic acid. Both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. The effects of dietary curcumin and ascorbyl palmitate on azoxymethanol (AOM)-induced hyperproliferation of colonic epithelial cells and the incidence of focal areas of dysplasia (FADs) were evaluated in female CF-1 mice fed an AIN 76A diet. Subcutaneous injections of AOM (10 mg/kg body wt. once weekly for 6 weeks) caused hyperplasia and the formation of FADs in the colon. Administration of 2% curcumin in the diet inhibited AOM-induced formation of FADs while administration of 2% ascorbyl palmitate in the diet did not demonstrate inhibition. This result suggests that dietary curcumin may inhibit AOM-induced colonic neoplasia in mice.