Improved prefrontal activity in AD/HD children treated with atomoxetine: A NIRS study
Improved prefrontal activity in AD/HD children treated with atomoxetine: A NIRS study
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DOI：
10.1016/j.braindev.2014.03.011
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发表时间：
2015-01-01
影响因子：
1.7
通讯作者：
Takahashi, Masaharu
中科院分区：
文献类型：
--
作者：
Araki, Akiko;Ikegami, Masanaga;Takahashi, Masaharu
背景/目的：托莫西汀（ATX）是一种选择性去甲肾上腺素再摄取抑制剂，是首个被批准用于治疗注意缺陷/多动障碍（AD/HD）的非兴奋剂药物。本研究使用近红外光谱（NIRS）检测了ATX长期治疗对AD/HD儿童在连续表现任务（CPT）期间前额叶血流动力学活动的影响。方法：在开始ATX治疗前和6个月或更长时间的实验期间，测量了12名AD/HD儿童的前额叶血流动力学活动。ATX的平均维持剂量为1.6 mg/kg/d。14名年龄匹配的典型发育儿童作为对照组。结果：在对照组中，CPT诱导双侧背外侧前额叶皮质（DLPFC）氧合血红蛋白（oxy-Hb）浓度显著升高。在atx前条件下的AD/HD组中，CPT没有诱导任何NIRS通道中的氧- hb浓度显著增加，但诱导左腹外侧前额叶皮质（VLPFC）中的氧- hb浓度显著降低。在atx后的AD/HD组中，右侧DLPFC明显激活，左侧VLPFC的氧- hb浓度下降消失。结论：这些结果表明，长期使用ATX治疗可改善AD/HD儿童前额叶血流动力学活性，NIRS可用于评估ATX治疗对前额叶血流动力学的反应。(C) 2014日本儿童神经病学学会。Elsevier B.V.版权所有。
Background/Aims: Atomoxetine (ATX), a selective norepinephrine reuptake inhibitor, is the first approved non-stimulant drug for treatment of attention deficit/hyperactivity disorder (AD/HD). The present study examined the effects of long-term treatment with ATX on prefrontal hemodynamic activity in AD/HD children during a continuous performance task (CPT) using near-infrared spectroscopy (NIRS). Methods: Prefrontal hemodynamic activity was measured in 12 children with AD/HD during experimental sessions conducted before and 6 months or more after starting ATX treatment. The average maintenance dose of ATX was 1.6 mg/kg/day. Fourteen age-matched typically developing children participated as a control group. Results: In the control group, the CPT induced a significant increase in oxygenated hemoglobin (oxy-Hb) concentration in the bilateral dorsolateral prefrontal cortex (DLPFC). In the AD/HD group in the pre-ATX condition, the CPT did not induce a significant increase in oxy-Hb concentration in any of the NIRS channels, but induced a significant decrease in oxy-Hb concentration in the left ventrolateral prefrontal cortex (VLPFC). In the AD/HD group in the post-ATX condition, significant activation was observed in the right DLPFC and the decrease in oxy-Hb concentration in the left VLPFC disappeared. Conclusions: These results suggest that long-term treatment with ATX improved prefrontal hemodynamic activity in AD/HD children, and NIRS may be useful for assessment of the prefrontal hemodynamic response to ATX treatment. (C) 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.