Role of leptin in the activation of immune cells.
Role of leptin in the activation of immune cells.
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DOI：
10.1155/2010/568343
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发表时间：
2010
影响因子：
4.6
通讯作者：
Sánchez-Margalet V
中科院分区：
文献类型：
--
作者：
Fernández-Riejos P;Najib S;Santos-Alvarez J;Martín-Romero C;Pérez-Pérez A;González-Yanes C;Sánchez-Margalet V
脂肪组织是一种分泌各种体液因子（脂肪因子）的活性内分泌器官，其在肥胖症中向促炎细胞因子产生的转变可能有助于低水平的全身性炎症，其可能存在于代谢综合征相关的慢性病理如动脉粥样硬化中。瘦素是脂肪细胞分泌的最重要的激素之一，具有多种生理作用，与代谢和能量稳态的控制有关。这些功能之一是营养状况和免疫能力之间的联系。脂肪细胞来源的激素瘦素已被证明在正常和病理条件下调节免疫应答，先天性和适应性应答。瘦素在调节免疫应答中的作用已经在体外以及临床研究中进行了评估。已经表明，瘦素产生减少的状况与感染易感性增加相关。相反，免疫介导的疾病如自身免疫性疾病与瘦素分泌增加和促炎性致病细胞因子的产生有关。因此，瘦素是炎症反应的介质。
Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines. Thus, leptin is a mediator of the inflammatory response.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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13.5
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