Unified synthesis of tirandamycins and streptolydigins
Unified synthesis of tirandamycins and streptolydigins
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DOI：
10.1039/c5cc07749d
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Hatakeyama, Susumi
中科院分区：
文献类型：
--
作者：
Yoshimura, Hikaru;Takahashi, Keisuke;Hatakeyama, Susumi
描述了 tirandamycins A-D 和 tirandalydigin 的不对称全合成以及从常见中间体合成链菌酮和链菌素左侧片段。该综合方法的特点是依赖于金鸡纳生物碱催化的不对称 Morita-Baylis-Hillman 反应，对反、反、顺式立体四元单元进行高度对映和非对映选择性组装。
The asymmetric total syntheses of tirandamycins A-D and tirandalydigin as well as the synthesis of the left-hand fragment of streptolydiginone and streptolydigin from a common intermediate are described. The comprehensive approach features the highly enantio-and diastereo-selective assembly of the anti, anti,syn-stereotetrad unit which relies on a cinchona alkaloid-catalyzed asymmetric Morita-Baylis-Hillman reaction.