Morphological Characteristics of Culprit Atheromatic Plaque Are Associated With Coronary Flow After Thrombolytic Therapy New Implications of Optical Coherence Tomography From a Multicenter Study
Morphological Characteristics of Culprit Atheromatic Plaque Are Associated With Coronary Flow After Thrombolytic Therapy New Implications of Optical Coherence Tomography From a Multicenter Study
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DOI：
10.1016/j.jcin.2010.02.010
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发表时间：
2010-05-01
影响因子：
11.3
通讯作者：
Stefanadis, Christodoulos
中科院分区：
文献类型：
--
作者：
Toutouzas, Konstantinos;Tsiamis, Elefterios;Stefanadis, Christodoulos
目的探讨ST段抬高型心肌梗死(STEMI)患者溶栓治疗后冠状动脉病变的光学相干断层成像(OCT)形态特征与TIMI血流分级的关系。背景：虽然已发现多个变量可预测STEMI患者溶栓后冠脉血流，但尚未研究罪犯病变形态对STEMI的影响。根据TIMI血流分级将患者分为TIMI血流3级和TIMI血流分级
Objectives This study investigated the association between morphological characteristics of culprit atheromatic lesions as assessed by optical coherence tomography and Thrombolysis In Myocardial Infarction (TIMI) flow grade after thrombolysis in patients with ST-segment elevation myocardial infarction (STEMI).Background Although several variables have been found to predict coronary flow after thrombolysis in patients with STEMI, the impact of culprit lesion morphology has not been studied.Methods Fifty-five patients with STEMI from 3 tertiary centers that were treated with thrombolysis and underwent optical coherence tomography examination in the culprit lesion between 24 and 48 h after thrombolysis were included in the study. Patients were categorized on the basis of TIMI flow grade into patients with TIMI flow grade 3 versus TIMI flow grade