Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso-ethmoidal complex
Role of endoscopic surgery in the management of selected malignant epithelial neoplasms of the naso-ethmoidal complex
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DOI：
10.1002/hed.20636
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发表时间：
2007-12-01
影响因子：
2.9
通讯作者：
Tomenzoli, Davide
中科院分区：
文献类型：
--
作者：
Nicolai, Piero;Castelnuovo, Paolo;Tomenzoli, Davide
背景。本研究回顾了鼻筛复合体腺癌（AC）和鳞状细胞癌（SCC）患者的内镜手术治疗的结果。16例患者在2所大学医院接受了纯内窥镜切除AC （n = 12）或SCC （n = 4）。所有患者前瞻性随访内镜和MRI评估。肿瘤起源于筛窦13例，起源于鼻窝3例。病变分期如下：5例T1, 10例T2, 1例T3。辅助放疗7例。所有患者均接受随访（28-70个月，平均47.25个月）。一名患者在手术后28个月死于脑转移。1例复发性AC患者需要补救性颅面切除术和放疗。5年疾病特异性生存率和无病生存率分别为93.3%和87.0%。在选定的鼻筛复合体T1-T2病变中，内窥镜手术似乎提供了一种令人满意的替代外部手术。(c) 2007 Wiley期刊公司
Background. This study reviews the outcome of patients with adenocarcinoma (AC) and squamous cell carcinoma (SCC) of the naso-ethmoidal complex treated by endoscopic surgery.Methods. Sixteen patients underwent a purely endoscopic excision of AC (n = 12) or SCC (n = 4) at 2 university hospitals. All patients were prospectively followed by endoscopic and MRI evaluations.Results. The tumor originated from the ethmoid in 13 cases and the nasal fossa in 3. Lesions were staged as follows: 5 T1, 10 T2, and 1 T3. Adjuvant radiotherapy was delivered in 7 cases. Follow-up (range, 28-70 months; mean, 47.25) was available for all patients. One patient died for brain metastases 28 months after surgery. Another patient required salvage craniofacial resection and radiotherapy for recurrent AC. Five-year disease-specific and disease-free survival rates were 93.3% and 87.0%, respectively.Conclusions. In selected T1-T2 lesions of the naso-ethmoidal complex, endoscopic surgery seems to offer a satisfactory alternative to external procedures. (c) 2007 Wiley Periodicals, Inc.