Development of the Crohn's disease digestive damage score, the Lémann score.
Development of the Crohn's disease digestive damage score, the Lémann score.
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DOI：
10.1002/ibd.21506
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发表时间：
2011-06
影响因子：
4.9
通讯作者：
Lemann, Marc
中科院分区：
文献类型：
--
作者：
Pariente, Benjamin;Cosnes, Jacques;Danese, Silvio;Sandborn, William J.;Lewin, Maite;Fletcher, Joel G.;Chowers, Yehuda;D'Haens, Geert;Feagan, Brian G.;Hibi, Toshifumi;Hommes, Daniel W.;Irvine, E. Jan;Kamm, Michael A.;Loftus, Edward V., Jr.;Louis, Edouard;Michetti, Pierre;Munkholm, Pia;Oresland, Tom;Panes, Julian;Peyrin-Biroulet, Laurent;Reinisch, Walter;Sands, Bruce E.;Schoelmerich, Juergen;Schreiber, Stefan;Tilg, Herbert;Travis, Simon;van Assche, Gert;Vecchi, Maurizio;Mary, Jean-Yves;Colombel, Jean-Frederic;Lemann, Marc
克罗恩病（CD）是一种慢性进行性破坏性疾病。目前可用的仪器可在特定时间点测量疾病活动。需要一种测量肠道累积结构损伤的仪器，以预测长期残疾。本文的目的是概述的方法，以开发一种仪器，可以测量累积肠损伤。该项目由国际克罗恩病新指标开发计划（IPNIC）小组实施。这种被称为克罗恩病消化系统损伤评分（l<s:1>曼分数）的工具，应考虑损伤的位置、严重程度、程度、进展和可逆性，通过诊断成像方式和手术切除史来衡量。它不应该是“诊断模式驱动”：对于每个病变和部位，将使用适合解剖部位的模式（例如：计算机断层扫描或磁共振成像肠造影和结肠镜检查）。来自15个国家的24个中心将参与一项横断面研究，其中将包括多达240名患者，根据疾病位置和持续时间进行分层。至少120名额外的患者将被纳入研究以验证评分。预期lsamimn评分能够在双轴图上描绘病人的病程，x轴为时间，y轴为肠损伤严重程度，连接数据点的直线斜率作为疾病进展的量度。该仪器可用于评估各种药物治疗对肠损伤进展的影响。（炎症肠病2011）
Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be “diagnostic modality driven”: for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lémann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage. (Inflamm Bowel Dis 2011)
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