Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude
Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude
复制标题
DOI：
10.1016/s0167-8760(03)00052-7
复制
发表时间：
2003-05-01
影响因子：
3
通讯作者：
McGue, M
中科院分区：
文献类型：
--
作者：
Iacono, WG;Malone, SM;McGue, M
我们假设存在一种遗传倾向，以行为去抑制为特征的一系列行为和特征。这种外化范围包括儿童期破坏性障碍、反社会行为、物质使用障碍、与行为控制不足有关的人格特征以及问题行为的早熟表现。我们进一步假设，遗传影响中枢神经系统素质的基础上，这一频谱，并反映在减少P300振幅在视觉古怪事件相关的潜在任务。对该模型的证据进行了回顾，其结果来自明尼苏达州双胞胎家庭研究，这是一项以人口为基础的双胞胎青年纵向调查。这些发现表明，与行为去抑制相关的属性集合是家族性的，遗传的，相互关联的。支持P3振幅降低（P3-AR）作为这种外化谱的遗传易感性指标的证据包括其与以下方面的关联：（a）物质使用和反社会人格障碍的家族风险，（B）儿童期破坏性障碍和物质使用障碍的诊断，（c）社会化不足行为的早期发作，以及（d）与外化问题相关的定量表型。此外，物质使用障碍在3年内的发展与P3-AR表达前测量相关。这些研究结果表明，P3-AR指数的遗传素质的一个方面的一系列外化的问题行为。(C)2003 Elsevier Science B. V.保留所有权利。
We hypothesize the existence of an inherited predisposition for a spectrum of behaviors and traits characterized by behavioral disinhibition. This externalizing spectrum includes childhood disruptive disorders, antisocial behavior, substance use disorders, personality traits related to behavioral undercontrol, and the precocious expression of problem behavior. We further hypothesize that a genetically influenced central nervous system diathesis underlies this spectrum and is reflected in reduced P300 amplitude in a visual oddball event-related potential task. A review of evidence bearing on the model is derived from findings from the Minnesota Twin Family Study, a population-based, longitudinal investigation of twin youth. These findings indicate that the collection of attributes related to behavioral disinhibition is familial, heritable, and interrelated. Evidence supporting P3 amplitude reduction (P3-AR) as an index of genetic vulnerability for this externalizing spectrum includes its association with (a) familial risk for substance use and antisocial personality disorders, (b) diagnoses of childhood disruptive disorders and substance use disorders, (c) early onset of undersocialized behavior, and (d) quantitative phenotypes related to externalizing problems. In addition, the development of substance use disorders over a 3-year period is associated with P3-AR measured prior to their expression. These findings suggest that P3-AR indexes one aspect of the genetic diathesis for a spectrum of externalizing problem behavior. (C) 2003 Elsevier Science B.V. All rights reserved.