Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories Improvement.
Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories Improvement.
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DOI：
10.3390/jof7070548
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发表时间：
2021-07-10
期刊：
影响因子：
--
通讯作者：
Madzak C
中科院分区：
文献类型：
--
作者：
Madzak C
在具有工业意义的非常规酵母中，二型产油酵母解脂耶氏酵母（Yarrowia lipolytica）对于从异源蛋白质分泌到细胞工厂工艺开发的大范围的白色生物技术应用而言似乎是最有吸引力的酵母之一。野生型，传统上改进或遗传修饰的解脂耶氏酵母菌株的过去，现在和潜在的应用将被恢复，连同广泛的分子工具，现在可用于遗传工程和代谢重塑这种酵母。本审查还将提供解脂耶氏酵母菌株的详细描述，并强调这种酵母的天然生物多样性，在大多数以前的评论很少触及的主题。这项工作旨在通过追溯工业利益的主要Yarrowia lipolytica菌株的系谱，通过说明新的遗传背景的搜索和通过提供有关全球酵母收藏中主要公开菌株的数据来填补这一空白。最后，它将集中在举例说明工程工具的进步如何能够利用更好的生物技术开发Yarrowia lipolytica和Yarrowia分支的其他酵母的天然生物多样性。
Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast Yarrowia lipolytica appears as one of the most attractive for a large range of white biotechnology applications, from heterologous proteins secretion to cell factories process development. The past, present and potential applications of wild-type, traditionally improved or genetically modified Yarrowia lipolytica strains will be resumed, together with the wide array of molecular tools now available to genetically engineer and metabolically remodel this yeast. The present review will also provide a detailed description of Yarrowia lipolytica strains and highlight the natural biodiversity of this yeast, a subject little touched upon in most previous reviews. This work intends to fill this gap by retracing the genealogy of the main Yarrowia lipolytica strains of industrial interest, by illustrating the search for new genetic backgrounds and by providing data about the main publicly available strains in yeast collections worldwide. At last, it will focus on exemplifying how advances in engineering tools can leverage a better biotechnological exploitation of the natural biodiversity of Yarrowia lipolytica and of other yeasts from the Yarrowia clade.
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作者：
Abbasi AR;Liu J;Wang Z;Zhao A;Ying H;Qu L;Alam MA;Xiong W;Xu J;Lv Y
通讯作者：
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