INCREASED RELEASE OF HYDROGEN-PEROXIDE (H2O2) AND SUPEROXIDE ANION (O-2-) BY MURINE MACROPHAGES INVITRO AFTER CISPLATIN TREATMENT
INCREASED RELEASE OF HYDROGEN-PEROXIDE (H2O2) AND SUPEROXIDE ANION (O-2-) BY MURINE MACROPHAGES INVITRO AFTER CISPLATIN TREATMENT
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DOI：
10.1016/0192-0561(86)90006-8
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
GUPTA, P
中科院分区：
文献类型：
--
作者：
SODHI, A;GUPTA, P
当鼠巨噬细胞（M. vphi.）用顺式铂（10 μ g或5 μ g/ml）处理单层30分钟、1、2、4、8和24小时，H2 O2的释放显著增加，**图形 **。通过m. vphi。被观察到。H2 O2的释放和.**图形 **。当M. vphi.用5 μ g/ml顺式铂处理，而不是10 μ g/ml。然而，观察到4小时顺式铂处理导致对H2 O2释放的相对抑制，并且 **图形 **。此外，我们还比较了H2 O2和.** 的释放。图形 **。通过m. vphi。用顺铂、LPS和PMA处理。
When murine macrophage (M.vphi.) monolayers are treated with cis-Platin (10 .mu.g or 5 .mu.g/ml) for 30 min, 1,2,4,8 and 24 h a significant increase in the release of H2O2 and .**GRAPHIC**. by M.vphi. is observed. The release of H2O2 and .**GRAPHIC**. was comparatively much more when M.vphi. were treated with 5 .mu.g/ml cis-Platin than 10 .mu.g/ml. However, it is observed that 4 h cis-Platin treatment results in comparative inhibition in the release of H2O2 and .**GRAPHIC**. Further, we compared the release of H2O2 and .**GRAPHIC**. by M.vphi. treated with cis-Platin, LPS and PMA.