Dietary Saturated Fatty Acid Intake and Early Age-Related Macular Degeneration in a Japanese Population
Dietary Saturated Fatty Acid Intake and Early Age-Related Macular Degeneration in a Japanese Population
复制标题
DOI：
10.1167/iovs.61.3.23
复制
发表时间：
2020-03-01
影响因子：
4.4
通讯作者：
Kawasaki, Ryo
中科院分区：
文献类型：
--
作者：
Sasaki, Mariko;Harada, Sei;Kawasaki, Ryo
目的。评估日本人群中膳食饱和脂肪酸（SFA）摄入与早期AMD存在的关系。以人群为基础的鹤冈代谢组学队列研究招募了年龄在35至74岁之间的普通人群，这些人来自日本鹤冈的年度健康检查项目的参与者，该项目包括眼底照片。共有4010人参加了基线调查。在排除了对饮食调查无反应和眼底图像质量次优的参与者后，3988名参与者（中位年龄62.4岁）被纳入了这项横断面分析。膳食摄入量通过有效的食物频率问卷进行评估。脂肪酸摄取量根据总能量摄取量用残差法调整。通过logistic回归模型评估脂肪酸摄入与早期AMD存在之间的关系。每日SFA摄入量中位数为11.3 g（四分位数范围为9.6 g, 13.0 g）。在对潜在的混杂因素进行调整后，与最低四分位数的参与者相比，SFA摄入量最高四分位数的参与者患早期AMD的可能性更小（优势比为0.71；95%可信区间为0.52-0.96）。随着SFA摄入量的增加，早期AMD的风险显著降低（P = 0.011）。多不饱和脂肪酸（PUFA）包括n3-PUFA的摄入与早期amd无显著关联。我们发现，在低SFA摄入量的日本人群中，SFA摄入量的增加与早期AMD风险的降低有关。足够的脂肪酸摄入可能需要维持视网膜稳态和预防AMD。
PURPOSE. To assess the association of dietary saturated fatty acid (SFA) intake with the presence of early AMD in a Japanese population.METHODS. The population-based Tsuruoka Metabolomics Cohort Study enrolled general population individuals aged 35 to 74 years from among participants in annual health check-up programs that included fundus photographs in Tsuruoka, Japan. A total of 4010 individuals participated in the baseline survey. After excluding nonresponders to a dietary survey and participants with suboptimal fundus image quality, 3988 participants (median age, 62.4 years) were included in this cross-sectional analysis. Dietary intake was assessed by a validated food frequency questionnaire. Fatty acids intake was adjusted for total energy intake by the residuals method. The association between fatty acid intake and presence of early AMD was assessed by logistic regression models.RESULTS. Median daily SFA intake was 11.3 g (interquartile range, 9.6, 13.0 g). After adjustments for potential confounding factors, participants in the highest quartile of SFA intake were less likely to have early AMD, compared with the lowest quartile (odds ratio, 0.71; 95% confidence interval: 0.52-0.96). A significant trend for decreased risk of early AMD with increasing SFA intake was noted (P = 0.011). There was no significant association between poly-unsaturated fatty acid (PUFA) including n3-PUFA intake and early AMD.CONCLUSIONS. We found that increased SFA intake was associated with reduced risk of early AMD in a Japanese population with low SFA intake. Adequate fatty acid intake may be required to maintain retinal homeostasis and prevent AMD.