Problems with tricyclic antidepressant use in patients with panic disorder or agoraphobia: results of a naturalistic follow-up study.
Problems with tricyclic antidepressant use in patients with panic disorder or agoraphobia: results of a naturalistic follow-up study.
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恐慌症或广场恐惧症患者使用三环类抗抑郁药的问题：自然主义随访研究的结果。
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
Linda Samuelson
中科院分区：
文献类型：
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作者：
Russell Noyes;Michael J. Garvey;B. L. Cook;Linda Samuelson
作者对 107 名惊恐障碍或伴有惊恐发作的广场恐惧症患者进行了随访，这些患者在 1 至 4 年前接受过三环类抗抑郁药治疗。百分之六十三的人报告在治疗期间至少有中等程度的改善；然而，副作用往往难以忍受，35% 的人因此停止了三环治疗。过度刺激是提前终止用药的最常见原因，占 20%，体重增加是后来停药的最常见原因，占 34%。 2 名患者出现癫痫发作。尽管鼓励他们停止用药，但大多数有反应的患者在随访中仍在服用药物。在停止药物治疗之前有反应的人中有一半以上随后复发。研究结果强调了焦虑症患者使用三环类抗抑郁药所带来的安全性、副作用和患者接受度方面的问题。
The authors followed up 107 patients with panic disorder or agoraphobia with panic attacks who had been placed on a regimen of tricyclic antidepressant treatment 1 to 4 years earlier. Sixty-three percent reported at least moderate improvement during treatment; however, side effects were often difficult to tolerate, and 35% discontinued tricyclic treatment on this account. Overstimulation, which occurred in 20%, was the most frequent reason for early termination, and weight gain, which occurred in 34%, was the most common reason for stopping the drug later on. Seizures occurred in 2 patients. Even though they were encouraged to discontinue drug use, most of the patients who had responded were still taking their drugs at follow-up. More than half of those who had responded before stopping drug treatment subsequently relapsed. The findings highlight problems with safety, side effects, and patient acceptance resulting from the use of tricyclic antidepressants in patients with anxiety disorders.