Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver
Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver
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DOI：
10.4049/jimmunol.168.4.1519
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发表时间：
2002-02-15
影响因子：
4.4
通讯作者：
Koziel, MJ
中科院分区：
文献类型：
--
作者：
Exley, MA;He, Q;Koziel, MJ
小鼠肝内淋巴细胞（IHL）主要由表达恒定T细胞受体α链、对CD1d有反应的NKT细胞组成，这些细胞可引发肝炎模型。恒定NKT（CD56(+/-)CD161(+)）以及近期发现的对CD1d有反应的非恒定T细胞可快速产生大量白细胞介素 - 4和/或干扰素 - γ，并能调节Th1/Th2反应。人类肝脏含有大量CD56(+) NKT细胞，但恒定NKT细胞很少。与匹配的外周血T细胞系相比，慢性丙型肝炎患者的原代肝内淋巴细胞系具有高水平的CD161和对CD1d的反应性，但恒定T细胞受体很少见。对CD1d有反应的肝内淋巴细胞明显偏向Th1。1311还显示出对CD1d特异的细胞毒活性。肝细胞和其他肝脏细胞表达CD1d。这些结果确定了一种新的人类T细胞群，它可能有助于肝脏中的破坏性免疫反应以及保护性免疫反应。对CD1d有反应的T细胞在不同组织中可能具有不同的作用。
Murine intrahepatic lymphocytes (IHL) are dominated by invariant TCR alpha-chain expressing CD1d-reactive NKT cells, which can cause model hepatitis. Invariant NKT (CD56(+/-)CD161(+)) and recently identified noninvariant CD1d-reactive T cells rapidly produce large amounts of IL-4 and/or IFN-gamma and can regulate Th1/Th2 responses. Human liver contains large numbers of CD56(+) NKT cells but few invariant NKT. Compared with matched peripheral blood T cell lines, primary IHL lines from patients with chronic hepatitis C had high levels of CD161 and CD1d reactivity, but the invariant TCR was rare. CD1d-reactive IHL were strikingly Th1 biased. 1311, also demonstrated CD1d-specific cytotoxic activity. Hepatocytes and other liver cells express CD1d. These results identify a novel population of human T cells that could contribute to destructive as well as protective immune responses in the liver. CD1d-reactive T cells may have distinct roles in different tissues.