Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography study
Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography study
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DOI：
10.1152/jn.00383.2014
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发表时间：
2014-10-01
影响因子：
2.5
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Heinrichs-Graham, Elizabeth;Kurz, Max J.;Wilson, Tony W.
帕金森病（PD）是一种进行性衰弱性神经退行性疾病，临床表现为运动、姿势和步态异常。记录丘脑底核内局部场电位和基于头皮的脑电图的人类神经生理学研究已经显示PD中整个基底节-丘脑-皮质运动网络的病理性β同步。值得注意的是，通过多巴胺替代疗法或脑深部刺激抑制这种病理性β同步与改善运动功能有关。然而，由于这些研究的侵入性，仍然不清楚这种“病理性β”是否真的比在健康人口统计学匹配的对照中观察到的更强。我们使用脑磁图来研究帕金森病患者和一组无神经系统疾病患者在静息状态下β范围和较低频率的神经元同步性和振荡幅度。在实际定义的药物“关闭”状态和给予多巴胺替代品后，对PD患者进行了研究。我们发现，与对照组相比，未用药的PD患者的初级运动区双侧β振荡幅度降低。给药可显著增加β振荡活性，因此具有正常化作用。有趣的是，我们还发现了明显更强的β同步（即，与对照组相比，未用药的PD患者的主要运动区域之间存在（超同步性），并且药物减少了这种耦合，这与术中研究一致。这些结果与已知的基底神经节-丘脑-皮质运动回路的功能和PD患者丘脑底核中β超同步的可能后果一致。
Parkinson's disease (PD) is a progressive debilitating neurodegenerative disorder clinically manifest by motor, posture and gait abnormalities. Human neurophysiological studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchrony throughout the basal ganglia-thalamic-cortical motor network in PD. Notably, suppression of this pathological beta synchrony by dopamine replacement therapy or deep-brain stimulation has been associated with improved motor function. However, due to the invasive nature of these studies, it remains unknown whether this "pathological beta" is actually stronger than that observed in healthy demographically matched controls. We used magnetoencephalography to investigate neuronal synchrony and oscillatory amplitude in the beta range and lower frequencies during the resting state in patients with PD and a matched group of patients without neurological disease. Patients with PD were studied both in the practically defined drug "OFF" state, and after administration of dopamine replacements. We found that beta oscillatory amplitude was reduced bilaterally in the primary motor regions of unmedicated patients with PD compared with controls. Administration of do medications significantly increased beta oscillatory activity, thus having a normalizing effect. Interestingly, we also found significantly stronger beta synchrony (i.e., hypersynchrony) between the primary motor regions in unmedicated patients with PD compared with controls, and that medication reduced this coupling which is in agreement with the intraoperative studies. These results are consistent with the known functionality of the basal ganglia-thalamic-cortical motor circuit and the likely consequences of beta hypersynchrony in the subthalamic nucleus of patients with PD.