Marsupellins A-F, ent-Longipinane-Type Sesquiterpenoids from the Chinese Liverwort Marsupella alpine with Acetylcholinesterase Inhibitory Activity
Marsupellins A-F, ent-Longipinane-Type Sesquiterpenoids from the Chinese Liverwort Marsupella alpine with Acetylcholinesterase Inhibitory Activity
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DOI：
10.1021/np4009255
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发表时间：
2014-04-01
影响因子：
5.1
通讯作者：
Lou, Hongxiang
中科院分区：
文献类型：
--
作者：
Zhang, Jiaozhen;Fan, Peihong;Lou, Hongxiang
乙酰胆碱酯酶(AChE)抑制活性引导的高山地钱分离得到6个新的[Marsupellins A-F(1-6)]和3个已知的(7-9)对端长松烷型倍半萜类化合物。通过MS和核磁共振波谱、单晶X-射线衍射和电子圆二色谱计算确定了它们的结构。化合物1-9表现出中等至弱的AChE抑制活性。
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of the Chinese liverwort Marsupella alpine afforded six new [marsupellins A-F (1-6)] and three known (7-9) ent-longipinane-type sesquiterpenoids. The structures were determined from MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1-9 exhibited moderate to weak AChE inhibitory activity.